Artículo de revista
Antinociceptive activity of Quillaja saponaria Mol. saponin extract, quillaic acid and derivatives in mice
Fecha
2011-01-07Registro en:
JOURNAL OF ETHNOPHARMACOLOGY Volume: 133 Issue: 1 Pages: 164-167 Published: JAN 7 2011
0378-8741
DOI: 10.1016/j.jep.2010.09.016
Autor
Arrau, Sylvia
Delporte Vergara, Carla
Cartagena, Carlos
Rodríguez Díaz, Maité
González, Patricia
Silva, Ximena
Cassels Niven, Bruce
Miranda Guzmán, Hugo
Institución
Resumen
Ethnopharmacological relevance: Quillaja saponaria bark contains a high percentage of triterpene saponins
and has been used for centuries as a cleansing and analgesic agent in Chilean folk medicine.
Aim of the study: The topical and systemic analgesic effects of a commercial partially purified saponin
extract, 3 ,16 -dihydroxy-23-oxoolean-12-en-28-oic acid (quillaic acid), methyl 3 ,16 -dihydroxy-23-
oxoolean-12-en-28-oate and methyl 4-nor-3,16-dioxoolean-12-en-28-oate.
Materials and methods: The samples were assessed in mice using the topical tail-flick and i.p. hot-plate
tests, respectively.
Results: All the samples showed activity in both analgesic tests in a dose-dependent manner. The most
active against tail flick test was commercial partially purified saponin extract (EC50 27.9 mg%, w/v) and
more than the ibuprofen sodium. On hot-plate test, methyl 4-nor-3, 16-dioxoolean-12-en-28-oate was
the most active (ED50 12.2 mg/kg) and more than the ibuprofen sodium.
Conclusions: The results of the present study demonstrated that Quillaja saponaria saponins, quillaic acid,
its methyl ester, and one of the oxidized derivatives of the latter, elicit dose-dependent antinociceptive
effects in two murine thermal models.