masterThesis
Disfunción tiroidea y VIH : prevalencia, correlación clínica e inmunológica en una cohorte de pacientes seropositivos
Fecha
2018Autor
Maldonado Lara, Eliana
Institución
Resumen
Introduction: Published data on the prevalence of thyroid dysfunction in HIV patients show heterogeneous information. The aim of the present study is to describe the prevalence of thyroid dysfunction in seropositive HIV patients. Methodology: Analytical study of a retrospective cohort of HIV seropositive individuals from the program of a tertiary hospital, where the TSH result taken from January 2011 to December 2015 was evaluated. Results: 1027 seropositive patients were included, the mean age was 48.2 ± 12.6 years, most males (84.5%). The mean of the CD4 lymphocyte count at the time of diagnosis was 298 ± 293.1 cell / mm3 and in the last control of 2015 of 430 ± 218.4 cell / mm3, according to the classification of the clinical stage (CDC Atlanta) 35.7% were C3. The prevalence of thyroid dysfunction was 24.5%, with the following distribution: clinical hypothyroidism 16.2%, subclinical hypothyroidism 7.9% and hyperthyroidism 0.2%. In the distribution by sex, hypothyroidism occurred in 30.1% of the total of women and 23.2% of the total of men. In multivariate analysis at higher age of patients and clinical stage C3 was positively associated with the presence of hypothyroidism. Conclusion: The association of hypothyroidism with age and clinical stage C3 was documented. There was no relationship of thyroid dysfunction with immune status. A higher prevalence of hypothyroidism was found in HIV patients versus the general population, with a predominance of clinical hypothyroidism.