dc.creator | Monterrubio, Carles | |
dc.creator | Paco, Sonia | |
dc.creator | Olaciregui, Nagore G. | |
dc.creator | Pascual Pasto, Guillem | |
dc.creator | Vila Ubach, Monica | |
dc.creator | Cuadrado Vilanova, Maria | |
dc.creator | Ferrandiz, M. Mar | |
dc.creator | Castillo Ecija, Helena | |
dc.creator | Glisoni, Romina Julieta | |
dc.creator | Kuplennik, Nataliya | |
dc.creator | Jungbluth, Achim | |
dc.creator | de Torres, Carmen | |
dc.creator | Lavarino, Cinzia | |
dc.creator | Cheung, N. K. V. | |
dc.creator | Mora, Jaume | |
dc.creator | Sosnik, Alejandro Dario | |
dc.creator | Montero Carcaboso, Angel | |
dc.date.accessioned | 2018-06-06T15:22:09Z | |
dc.date.available | 2018-06-06T15:22:09Z | |
dc.date.created | 2018-06-06T15:22:09Z | |
dc.date.issued | 2017-06 | |
dc.identifier | Monterrubio, Carles; Paco, Sonia; Olaciregui, Nagore G.; Pascual Pasto, Guillem; Vila Ubach, Monica; et al.; Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8; Elsevier Science; Journal of Controlled Release; 255; 6-2017; 108-119 | |
dc.identifier | 0168-3659 | |
dc.identifier | http://hdl.handle.net/11336/47474 | |
dc.identifier | CONICET Digital | |
dc.identifier | CONICET | |
dc.description.abstract | Neuroblastoma is a pediatric solid tumor with high expression of the tumor associated antigen disialoganglioside GD2. Despite initial response to induction therapy, nearly 50% of high-risk neuroblastomas recur because of chemoresistance. Here we encapsulated the topoisomerase-I inhibitor SN-38 in polymeric nanoparticles (NPs) surface-decorated with the anti-GD2 mouse mAb 3F8 at a mean density of seven antibody molecules per NP. The accumulation of drug-loaded NPs targeted with 3F8 versus with control antibody was monitored by microdialysis in patient-derived GD2-expressing neuroblastoma xenografts. We showed that the extent of tumor penetration by SN-38 was significantly higher in mice receiving the targeted nano-drug delivery system when compared to non-targeted system or free drug. This selective penetration of the tumor extracellular fluid translated into a strong anti-tumor effect prolonging survival of mice bearing GD2-high neuroblastomas in vivo. | |
dc.language | eng | |
dc.publisher | Elsevier Science | |
dc.relation | info:eu-repo/semantics/altIdentifier/doi/https://dx.doi.org/10.1016/j.jconrel.2017.04.016 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0168365917305357 | |
dc.relation | info:eu-repo/semantics/altIdentifier/url/https://pubmed.ncbi.nlm.nih.gov/28412222/ | |
dc.rights | https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ | |
dc.rights | info:eu-repo/semantics/openAccess | |
dc.subject | Gd2-Targeted Nanoparticles | |
dc.subject | Intratumor Drug Distribution | |
dc.subject | Microdialysis | |
dc.subject | Tumor Extracellular Fluid | |
dc.subject | Neuroblastoma | |
dc.subject | Irinotecan/Sn-38 | |
dc.subject | Pdx Models | |
dc.title | Targeted drug distribution in tumor extracellular fluid of GD2-expressing neuroblastoma patient-derived xenografts using SN-38-loaded nanoparticles conjugated to the monoclonal antibody 3F8 | |
dc.type | info:eu-repo/semantics/article | |
dc.type | info:ar-repo/semantics/artículo | |
dc.type | info:eu-repo/semantics/publishedVersion | |