Artículos de revistas
Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34
Fecha
2014-11Registro en:
Demicheli, Veronica; Moreno, Diego Martin; Jara, Gabriel Ernesto; Carballal, Sebastian; Quijano, Celia; et al.; Mechanism of the Reaction of Peroxynitrite with Mn-Superoxide Dismutase: Nitration of Critical Tyrosine-34; Elsevier Science Inc; Free Radical Biology and Medicine; 76; 11-2014; 138-139
0891-5849
CONICET Digital
CONICET
Autor
Demicheli, Veronica
Moreno, Diego Martin
Jara, Gabriel Ernesto
Carballal, Sebastian
Quijano, Celia
Ferrer Sueta, Gerardo
Rios, Natalia
Estrin, Dario Ariel
Marti, Marcelo Adrian
Radi, Rafael
Resumen
Manganese superoxide dismutase (MnSOD) is an antioxidantenzyme that acts as a superoxide detoxifier. Superoxide can reactwith nitric oxide to lead peroxynitrite and this reaction, that takesplace at near diffusion limited rates, can compete with MnSOD forsuperoxide. One of the most important bio-markers forperoxynitrite formation in vivo is tyrosine nitration, a posttranslationalmodification that can alter both the structure andfunction of a protein.