info:eu-repo/semantics/article
Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis
Fecha
2000-04Registro en:
Meresman, Gabriela Fabiana; Vighi, Susana; Buquet, Ricardo A.; Contreras Ortiz, Oscar; Tesone, Marta; et al.; Apoptosis and expression of Bcl-2 and Bax in eutopic endometrium from women with endometriosis; Elsevier Science Inc; Fertility and Sterility; 74; 4; 4-2000; 760-766
0015-0282
1556-5653
CONICET Digital
CONICET
Autor
Meresman, Gabriela Fabiana
Vighi, Susana
Buquet, Ricardo A.
Contreras Ortiz, Oscar
Tesone, Marta
Rumi, Lia S.
Resumen
To evaluate and compare spontaneous apoptosis and Bcl-2 and Bax expression in eutopic endometrium from women with and without endometriosis. Spontaneous apoptosis was significantly lower in eutopic endometrium from patients with endometriosis, compared with healthy controls (2.26 +/- 0.53 and 9.37 +/- 1.69 apoptotic cells/field, respectively) and was independent of cycle phase. An increased expression of Bcl-2 protein was found in proliferative eutopic endometrium from patients with endometriosis. Bax expression was absent in proliferative endometrium, whereas there was an increase in its expression in secretory endometrium from both patients and controls.Women with endometriosis show decreased number of apoptotic cells in eutopic endometrium. The abnormal survival of endometrial cells may result in their continuing growth into ectopic locations