Artículos de revistas
Glycemic control and arterial stiffness in a Brazilian rural population: Baependi Heart Study
Fecha
2015Registro en:
Diabetology & Metabolic Syndrome. 2015 Oct 06;7(1):86
10.1186/s13098-015-0082-8
Autor
Alvim, Rafael de Oliveira
Mourao-Junior, Carlos Alberto
Oliveira, Camila Maciel de
Lima, Rerisson de Faria
Horimoto, Andréa Roseli Vançan Russo
Hong, Valéria Aparecida da Costa
Bortolotto, Luiz Aparecido
Krieger, José Eduardo
Pereira, Alexandre Costa
Institución
Resumen
Abstract
Background
Increased arterial stiffness predicts morbidity and mortality, independently of other cardiovascular risk factors, and glycemic control impairments are related to higher vascular stiffness. The aim of this study was to evaluate the association between HbA1c levels and increased arterial stiffness in a Brazilian rural population.
Methods
For this study were selected 1675 individuals (both genders and aged over 18 years) resident in the municipality of Baependi, a city located in the Southeast of Brazil. HbA1c levels were determined by HPLC. Pulse wave velocity (PWV) was measured with a non-invasive automatic device (Complior).
Results
HbA1c levels were associated with an increased PWV. This was more relevant for the third tertile of age. In addition, logistic regression multivariate model including age, blood pressure, gender, BMI and fasting glucose showed that the elevation of a single unit percentage of HbA1c represented an increase of 54 % in the odds of increased arterial stiffness [OR 1.54 (95 % CI 1.01–2.17)]. Both, HbA1c and fasting glucose showed higher discriminatory power in the risk assessment for increased arterial stiffness in the non-diabetic when compared to the diabetic group (AUC of HbA1c = 0.71 vs 0.57, p = 0.02; AUC of fasting glucose = 0.66 vs 0.45, p = 0.0007, respectively).
Conclusion
Our findings indicate that a increase in HbA1c levels is associated with increased arterial stiffness and that both, HbA1c and fasting glucose, presented higher discriminatory power in the risk assessment for increased arterial stiffness in the non-diabetic group as compared to diabetic individuals.