Artículos de revistas
A new dic(7;12)(p12.21;p12.2) and i(12)(q10) during the lymphoid blast crisis of patient with Ph plus chronic myeloid leukemia
Fecha
2012Registro en:
MEDICAL ONCOLOGY, TOTOWA, v. 29, n. 4, p. 2332-2336, DEC, 2012
1357-0560
10.1007/s12032-011-0142-3
Autor
Oliveira, Fabio Morato de
Palma, Leonardo de Carvalho
Falcão, Roberto Passetto
Simoes, Belinda Pinto
Institución
Resumen
Chronic myelogenous leukemia (CML) is a common myeloproliferative disease that is characterized by the clonal expansion of marrow stem cells, and is associated with the Philadelphia chromosome. As the disease progresses, additional chromosome abnormalities may arise. The prognostic impact of secondary chromosomal abnormalities in CML is complex, heterogeneous, and sometimes related to previous treatment. Here, we describe a CML patient in lymphoid blast crisis associated with a new chromosomal abnormality identified, dic(7;12)(p12.21;p12.2) and i(12)(q10) using classical cytogenetics and spectral karyotype analysis. To the best of our knowledge, this is the first report of t(7;12)(p11.1;q11.1) and i(12)(q10) in a CML patient with lymphoid evolution.