Artículos de revistas
Synthesis, characterization and evaluation of antileishmanial activity of copper(II) with fluorinated alpha-hydroxycarboxylate ligands
Fecha
2009Registro en:
BIOMETALS, v.22, n.6, p.1095-1101, 2009
0966-0844
10.1007/s10534-009-9260-1
Autor
MAFFEI, Rodrigo da Silva
YOKOYAMA-YASUNAKA, Jenicer K. U.
MIGUEL, Danilo Ciccone
ULIANA, Silvia Reni Bortolin
ESPOSITO, Breno Pannia
Institución
Resumen
In this study, Cu(II) complexes with fluorinated ligands were produced aiming at the development of new, less toxic antileishmanial metallodrugs. Complexes of the general formula CuL(2) (L = lactate, trifluorolactate, 2-hydroxyisobutyrate, trifluoro-2-hydroxyisobutyrate) were synthesized in methanolic medium, purified by crystallization and characterized by elemental analysis and electronic and infrared spectroscopies. In vitro experiments with Leishmania amazonensis promastigotes showed that the trifluorolactate derivative more active than its non-fluorinated counterpart. Our results indicate that fluorinated chelators may be interesting to increase metal toxicity and/or open new paths for metallodrug chemotherapy against leishmaniasis.