dc.creator | SANTIAGO, Nivia M. | |
dc.creator | GUIMARAES, Priscila S. | |
dc.creator | SIRVENTE, Raquel A. | |
dc.creator | OLIVEIRA, Laser A. M. | |
dc.creator | IRIGOYEN, Maria C. | |
dc.creator | SANTOS, Robson A. S. | |
dc.creator | CAMPAGNOLE-SANTOS, Maria J. | |
dc.date.accessioned | 2012-10-20T02:56:34Z | |
dc.date.accessioned | 2018-07-04T15:30:50Z | |
dc.date.available | 2012-10-20T02:56:34Z | |
dc.date.available | 2018-07-04T15:30:50Z | |
dc.date.created | 2012-10-20T02:56:34Z | |
dc.date.issued | 2010 | |
dc.identifier | HYPERTENSION, v.55, n.4, p.889-U134, 2010 | |
dc.identifier | 0194-911X | |
dc.identifier | http://producao.usp.br/handle/BDPI/27214 | |
dc.identifier | 10.1161/HYPERTENSIONAHA.110.149815 | |
dc.identifier | http://dx.doi.org/10.1161/HYPERTENSIONAHA.110.149815 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1623864 | |
dc.description.abstract | We evaluated the development of arterial hypertension, cardiac function, and collagen deposition, as well as the level of components of the renin-angiotensin system in the heart of transgenic rats that overexpress an angiotensin (Ang)-(1-7)-producing fusion protein, TGR(A1-7)3292 (TG), which induces a lifetime increase in circulating levels of this peptide. After 30 days of the induction of the deoxycorticosterone acetate (DOCA)-salt hypertension model, DOCA-TG rats were hypertensive but presented a lower systolic arterial pressure in comparison with DOCA-Sprague-Dawley (SD) rats. In contrast to DOCA-SD rats that presented left ventricle (LV) hypertrophy and diastolic dysfunction, DOCA-TG rats did not develop cardiac hypertrophy or changes in ventricular function. In addition, DOCA-TG rats showed attenuation in mRNA expression for collagen type I and III compared with the increased levels of DOCA-SD rats. Ang II plasma and LV levels were reduced in SD and TG hypertensive rats in comparison with normotensive animals. DOCA-TG rats presented a reduction in plasma Ang-(1-7) levels; however, there was a great increase in Ang-(1-7) (approximate to 3-fold) accompanied by a decrease in mRNA expression of both angiotensin-converting enzyme and angiotensin-converting enzyme 2 in the LV. The mRNA expression of Mas and Ang II type 1 receptors in the LV was not significantly changed in DOCA-SD or DOCA-TG rats. This study showed that TG rats with increased circulating levels of Ang-(1-7) are protected against cardiac dysfunction and fibrosis and also present an attenuated increase in blood pressure after DOCA-salt hypertension. In addition, DOCA-TG rats showed an important local increase in Ang-(1-7) levels in the LV, which might have contributed to the attenuation of cardiac dysfunction and prefibrotic lesions. (Hypertension. 2010;55:889-896.) | |
dc.language | eng | |
dc.publisher | LIPPINCOTT WILLIAMS & WILKINS | |
dc.relation | Hypertension | |
dc.rights | Copyright LIPPINCOTT WILLIAMS & WILKINS | |
dc.rights | restrictedAccess | |
dc.subject | angiotensin-(1-7) | |
dc.subject | cardiac remodeling | |
dc.subject | cardiac function | |
dc.subject | hypertension | |
dc.title | Lifetime Overproduction of Circulating Angiotensin-(1-7) Attenuates Deoxycorticosterone Acetate-Salt Hypertension-Induced Cardiac Dysfunction and Remodeling | |
dc.type | Artículos de revistas | |