Artículos de revistas
Emergence of Klebsiella pneumoniae carrying the novel extended-spectrum beta-lactamase gene variants bla(SHV-40), bla(TEM-116) and the class 1 integron-associated bla(GES-7) in Brazil
Fecha
2010Registro en:
CLINICAL MICROBIOLOGY AND INFECTION, v.16, n.6, p.630-632, 2010
1198-743X
10.1111/j.1469-0691.2009.02944.x
Autor
DROPA, M.
BALSALOBRE, L. C.
LINCOPAN, N.
MAMIZUKA, E. M.
CASSETTARI, V. C.
MATTE, G. R.
MATTE, M. H.
Institución
Resumen
A clinical Klebsiella pneumoniae isolate carrying the extended-spectrum beta-lactamase gene variants bla(SHV-40), bla(TEM-116) and bla(GES-7) was recovered. Cefoxitin and ceftazidime activity was most affected by the presence of these genes and an additional resistance to trimethoprim-sulphamethoxazole was observed. The bla(GES-7) gene was found to be inserted into a class 1 integron. These results show the emergence of novel bla(TEM) and bla(SHV) genes in Brazil. Moreover, the presence of class 1 integrons suggests a great potential for dissemination of bla(GES) genes into diverse nosocomial pathogens. Indeed, the bla(GES-7) gene was originally discovered in Enterobacter cloacae in Greece and, to our knowledge, has not been reported elsewhere.