Artículos de revistas
Multiple ADH genes are associated with upper aerodigestive cancers
Fecha
2008Registro en:
NATURE GENETICS, v.40, n.6, p.707-709, 2008
1061-4036
10.1038/ng.151
Autor
HASHIBE, Mia
MCKAY, James D.
CURADO, Maria Paula
OLIVEIRA, Jose Carlos
KOIFMAN, Sergio
KOIFMAN, Rosalina
ZARIDZE, David
SHANGINA, Oxana
WÜNSCH-FILHO, Victor
ELUF-NETO, Jose
LEVI, Jose Eduardo
MATOS, Elena
LAGIOU, Pagona
LAGIOU, Areti
BENHAMOU, Simone
BOUCHARDY, Christine
SZESZENIA-DABROWSKA, Neonilia
MENEZES, Ana
DALL`AGNOL, Marinel Mor
MERLETTI, Franco
RICHIARDI, Lorenzo
FERNANDEZ, Leticia
LENCE, Juan
TALAMINI, Renato
BARZAN, Luigi
MATES, Dana
MATES, Ioan Nicolae
KJAERHEIM, Kristina
MACFARLANE, Gary J.
MACFARLANE, Tatiana V.
SIMONATO, Lorenzo
CANOVA, Cristina
HOLCATOVA, Ivana
AGUDO, Antonio
CASTELLSAGUE, Xavier
LOWRY, Ray
JANOUT, Vladimir
KOLLAROVA, Helena
CONWAY, David I.
MCKINNEY, Patricia A.
ZNAOR, Ariana
FABIANOVA, Eleonora
BENCKO, Vladimir
LISSOWSKA, Jolanta
CHABRIER, Amelie
HUNG, Rayjean J.
GABORIEAU, Valerie
BOFFETTA, Paolo
BRENNAN, Paul
Institución
Resumen
Alcohol is an important risk factor for upper aerodigestive cancers and is principally metabolized by alcohol dehydrogenase (ADH) enzymes. We have investigated six ADH genetic variants in over 3,800 aerodigestive cancer cases and 5,200 controls from three individual studies. Gene variants rs1229984 (ADH1B) and rs1573496 (ADH7) were significantly protective against aerodigestive cancer in each individual study and overall (P = 10(-10) and 10(-9), respectively). These effects became more apparent with increasing alcohol consumption (P for trend = 0.0002 and 0.065, respectively). Both gene effects were independent of each other, implying that multiple ADH genes may be involved in upper aerodigestive cancer etiology.