Artículos de revistas
Circulating Concentrations Of Adipocytokines And Their Receptors In The Isolate Corpus Cvernosum And Femoral Artery From Trained Rats On A High-fat Diet
Registro en:
Journal Of Vascular Research. Karger, v. 54, p. 33 - 50, 2017.
1018-1172
1423-0135
WOS:000399173100004
10.1159/000457800
Autor
Sponton
Amanda C. S.; Silva
Fabio H.; Araujo
Hygor N.; da Silva
Carmem P. Valgas; de Moraes
Camila; Antunes
Edson; Zanesco
Angelina; Delbin
Maria A.
Institución
Resumen
Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Background: The aim of the present study was to evaluate different signaling pathways by which exercise training would interfere in endothelial function in obesity. Therefore, we examined adipocytokine levels and their receptors in the corpus cavernosum and femoral artery from trained rats on a high-fat diet. Methods: Functional experiments were performed in control sedentary and trained rats, and sedentary (h-SD) and trained male Wistar rats on a high-fat diet (h-TR). Nitric oxide (NO) and reactive oxygen species (ROS) were evaluated in vascular tissue. Circulating adipocytokines and their receptors were analyzed. Results: In the h-SD group, the maximal responses to acetylcholine (ACh) were reduced in the femoral artery and corpus cavernosum as well as the electrical field stimulation, accompanied by an increase in circulating insulin, leptin, TNF-alpha, MCP-1, and PAI-1. Downregulation of ObR protein expression in the femoral artery was observed without alterations in AdipoR1 and TNFR1 in both prepara-tions. A positive effect was observed in the h-TR group regarding the relaxation response to ACh and circulating adipocytokines, resulting in increased NO production and reduced ROS generation. Exercise restored the ObR protein expression only in the femoral artery. Conclusion: Aerobic exercise training ameliorated the inflammatory adipocytokines and restored the relaxation responses in the corpus cavernosum and femoral artery in rats on a high-fat diet. (C) 2017 S. Karger AG, Basel 54 1 33 50 CNPq [441514/2014-6] FAPESP [2013/26886-4] PEMBERTON Coca-Cola Brasil Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)