Artículos de revistas
Thymic Alterations Induced By Plasmodium Berghei: Expression Of Matrix Metalloproteinases And Their Tissue Inhibitors.
Cellular Immunology. v. 279, n. 1, p. 53-9, 2012-Sep.
Lima, Alliny Carolina Dionete
Ferrucci, Danilo Lopes
Stach-Machado, Dagmar Ruth
The thymus plays a crucial role in the generation of T-cells, and so our laboratory has been interested in the study of the intrathymic events that occur during infection diseases and may cause disruption in its functions. Previously, we showed that thymus from experimentally Plasmodium berghei-infected mice present histological alterations with high levels of apoptosis, changes in cell migration-related molecules, and premature egress of immature thymocytes to periphery. In addition, parasites were found inside the thymus. In this work we investigated alterations in the expression pattern and activity of matrix metalloproteinases MMP-2 and -9, and their tissue inhibitors, TIMP-1 and TIMP-2. Our results show enhanced expression and widespread distribution of these molecules in thymus from infected animals. Also, the presence of active MMP-2 was detected. These data are suggestive of MMPs and TIMPs importance in the earlier observed changes in the extracellular matrix during thymic alterations after plasmodium infection.27953-9
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Tissue inhibitor of metalloproteinase-2 (TIMP-2) location in the ventral, lateral, dorsal and anterior lobes of rat prostate by immunohistochemistry Delella, Flávia K.; Justulin Jr., Luis A.; Felisbino, Sérgio L.
Tissue inhibitor of metalloproteinase-2 (TIMP-2) location in the ventral, lateral, dorsal and anterior lobes of rat prostate by immunohistochemistry Universidade Estadual de Campinas (UNICAMP); Universidade Estadual Paulista (UNESP) (2007-03-01)Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) play a major role in extracellular matrix component degradation in several normal and abnormal tissue situations; they are also found in human seminal ...
Jucá, Mário; Nunes, Benicio Luiz Bulhões Barros Paula; Menezes, Hunaldo Lima De; Gomes, Edmundo Guilherme De Almeida; Matos, Delcio (Cidade Editora Científica Ltda, 2008-09-01)The metalloproteinase-1 (MMP-1) and metalloproteinase-7 (MMP-7) are proteinases of the extracellular matrix (MEC), zinc-dependent, involved in the initial process of carcinogenesis, allowing the invasion by the tumor cell ...