[effects Of Omega-3 Acids On Endothelium-dependent Relaxation In Hypercholesterolemic Rabbits].

dc.creatorJorge, P A
dc.creatorNeyra, L C
dc.creatorOzaki, R M
dc.creatorde Almeida, E
dc.date1997-Jul
dc.date2015-11-27T12:19:05Z
dc.date2015-11-27T12:19:05Z
dc.date.accessioned2018-03-29T00:52:30Z
dc.date.available2018-03-29T00:52:30Z
dc.identifierArquivos Brasileiros De Cardiologia. v. 69, n. 1, p. 13-8, 1997-Jul.
dc.identifier0066-782X
dc.identifier
dc.identifierhttp://www.ncbi.nlm.nih.gov/pubmed/9532810
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/194100
dc.identifier9532810
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1294333
dc.descriptionTo study the effect of omega-3 fatty acid on endothelium-dependent relaxation, total plasma cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides levels as well as, the malondialdehyde (MDA) content of the LDL particles and arterial wall. Fourteen male rabbits were randomly assigned to hypercholesterolemic and omega-3 groups. The dose of omega-3 fatty acid utilized was 300g/kg/day during 15 days. All rabbits were fed a diet supplemented with cholesterol (0.5%) and coconut oil (2%) for four weeks. At the end of the experiment the animals were killed and the aorta removed for measurement of MDA content and the endothelium-dependent relaxation studies. Total plasma cholesterol, VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides was measured by enzymatic kits. MDA was also measured in natives and oxidized LDL and arterial wall. Cholesterol and VLDL-cholesterol were increased significantly in the omega-3 treated animals. The triglyceride level was significantly reduced (p < 0.05). The MDA content was increased in the LDL particles and in the arterial wall (p < 0.05). Endothelium-dependent relaxation was significantly reduced (p < 0.05). Omega-3 fatty acid impairs the endothelium-dependent relaxation when administered to cholesterol fed rabbits, increases the cholesterol and reduces the triglycerides plasma levels. The lipid peroxidation of the LDL particles and arterial wall was increased.
dc.description69
dc.description13-8
dc.languagepor
dc.relationArquivos Brasileiros De Cardiologia
dc.relationArq. Bras. Cardiol.
dc.rightsaberto
dc.rights
dc.sourcePubMed
dc.subjectAnimals
dc.subjectCholesterol, Hdl
dc.subjectCholesterol, Ldl
dc.subjectCholesterol, Vldl
dc.subjectEndothelium
dc.subjectFatty Acids, Omega-3
dc.subjectHypercholesterolemia
dc.subjectNitric Oxide
dc.subjectRabbits
dc.subjectTriglycerides
dc.title[effects Of Omega-3 Acids On Endothelium-dependent Relaxation In Hypercholesterolemic Rabbits].
dc.typeArtículos de revistas


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