Artículos de revistas
Influence of stimulus frequency on blockade induced by pancuronium and rocuronium. Study on rats phrenic nerve-diaphragm preparation
Registro en:
Acta Cirurgica Brasileira. Acta Cirurgica Brasileira, v. 22, n. 6, n. 446, n. 450, 2007.
0102-8650
WOS:000258573500006
10.1590/S0102-86502007000600006
Autor
Braga, ADD
Munoz, DC
Braga, FSD
de Araujo, DR
Poterio, MB
Mantovani, M
Institución
Resumen
Purpose: To evaluate the influence of two stimulation frequencies on the installation of neuromuscular blockade produced by pancuronium and rocuronium on the rat diaphragm. Methods: Diaphragms were submitted to an indirect frequency stimulation of 0.1 and 1 Hz (Groups I and II, respectively). Subgroups were formed (n=5) according to the neuromuscular blocker employed (pancuronium-2 mu g/ml and rocuronium-4 mu g/ml). The twitch height depression was evaluated at 5, 15 and 30 minutes after adding the neuromuscular blocker. Results: The decrease in twitch height was greater (p<0.01) with a frequency of I Hz at all time periods studied both in preparations that are blocked with pancuronium and in those that are blocked with rocuronium. Conclusion: The frequency of stimulation interferes significantly with the installation of neuromuscular blockade produced by pancuronium and rocuronium, since the reduction in amplitude of the rat diaphragm response was greater for I Hz frequencies, at all periods studied. 22 6 446 450