INHIBITION OF DNA-POLYMERASE ALPHA AND REVERSE-TRANSCRIPTASE ACTIVITIES BY HPA-23

dc.creatorAOYAMA, H
dc.creatorJUCA, MB
dc.creatorZOURGUI, L
dc.creatorLITVAK, S
dc.date1991
dc.date2014-08-01T18:32:54Z
dc.date2015-11-26T17:03:42Z
dc.date2014-08-01T18:32:54Z
dc.date2015-11-26T17:03:42Z
dc.date.accessioned2018-03-28T23:51:51Z
dc.date.available2018-03-28T23:51:51Z
dc.identifierArquivos De Biologia E Tecnologia. Inst Tecnologia Parana, v. 34, n. 41732, n. 459, n. 466, 1991.
dc.identifier0365-0979
dc.identifierWOS:A1991HP88000010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80576
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/80576
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1279146
dc.descriptionWe describe the effect of HPA-23 in the DNA synthesis reaction catalyzed by DNA polymerase-alpha and reverse transcriptase. 0.085 and 0.017-mu-M of HPA-23 inhibited 50% of DNA polymerase alpha-activity in the presence of activated DNA and poly(dA)-oligo(dT), respectively. However, for reverse transcriptase, this same effect was observed only with 6.76-mu-M of the drug independently of the template-primer used (activated DNA or poly (rA)-oligo(dT)). HPA-23 was a non-competitive inhibitor with respect to activated DNA and to TTP in the DNA polymerase alpha-reaction.
dc.description34
dc.description41732
dc.description459
dc.description466
dc.languagept
dc.publisherInst Tecnologia Parana
dc.publisherCuritiba-parana
dc.publisherBrasil
dc.relationArquivos De Biologia E Tecnologia
dc.relationArq. Biol. Tecnol.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectDNA POLYMERASE
dc.subjectREVERSE TRANSCRIPTASE
dc.subjectHPA-23
dc.subjectINHIBITION
dc.titleINHIBITION OF DNA-POLYMERASE ALPHA AND REVERSE-TRANSCRIPTASE ACTIVITIES BY HPA-23
dc.typeArtículos de revistas


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