Artículos de revistas
Antiproliferative activity, isolation and identification of active compound from Gaylussacia brasiliensis
Registro en:
Revista Brasileira De Farmacognosia-brazilian Journal Of Pharmacognosy. Soc Brasileira Farmacognosia, v. 21, n. 4, n. 622, n. 626, 2011.
0102-695X
WOS:000294123100010
10.1590/S0102-695X2011005000116
Autor
Rodrigues, RAF
de Carvalho, JE
Sousa, IMD
Antonio, MA
Pizao, PE
Kohn, LK
do Amaral, MDE
Bittrich, V
Foglio, MA
Institución
Resumen
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Gaylussacia brasiliensis (Spreng.) Meissn., Ericaceae, is used in folk medicine for treatment of several inflammatory processes and as healing agent. The scope of this work was to evaluate the in vitro antiproliferative activity of crude dichloromethane extract (CHD) and to identify the compound(s) responsible for this activity. CHD was evaluated and showed a concentration dependent inhibition on all cells lines. Therefore CHD was submitted to several classical columns chromatography providing the most active fraction (FC), inhibiting all cells line at 25 mu g/mL. FC was further fractionated affording isolated compound 2 beta, 3 beta-dihydroxy-urs-12-ene-28-oic acid, identified on basis of 2D-NMR experiments and showed concentration-dependent activity and selectivity for kidney and breast cell lines. 21 4 622 626 Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) Conselho Nacional de Pesquisas Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)