Chemical Composition and Cytotoxic Activity of Essential Oil from Myrcia laruotteana Fruits

dc.creatorStefanello, MEA
dc.creatorRiva, D
dc.creatorSimionatto, EL
dc.creatorde Carvalho, JE
dc.creatorRuiz, ALTG
dc.creatorSalvador, MJ
dc.date2011
dc.dateSEP-OCT
dc.date2014-07-30T16:52:16Z
dc.date2015-11-26T16:29:28Z
dc.date2014-07-30T16:52:16Z
dc.date2015-11-26T16:29:28Z
dc.date.accessioned2018-03-28T23:10:31Z
dc.date.available2018-03-28T23:10:31Z
dc.identifierJournal Of Essential Oil Research. Taylor & Francis Inc, v. 23, n. 5, n. 7, n. 10, 2011.
dc.identifier1041-2905
dc.identifierWOS:000295246900002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/62991
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/62991
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269731
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe essential oil isolated by hydrodistillation from unripe fruits of Myrcia laruotteana Camb. (Myrtaceae) was analyzed by GC and CG/MS. Forty-four components were identified, representing around 83% of total oil. The major components were a-bisabolol (23.6%) and a-bisabolol oxide B (11.5%). The cytotoxicity of the oil and of a fraction rich in a-bisabolol was tested in vitro against U251 (glioma), UACC-62 (melanoma), MCF-7 (breast), NC1-ADR/RES (ovarian-resistant), 786.0 (kidney), NCI-H460 (lung), PC-3 (prostate), OVCAR-3 (ovarian), HT-29 (colon) and K562 (leukemia) human cancer cells and against VERO (no cancer cell). The oil exhibited antiproliferative activity against all cell lines (TGI < 100 mu g/mL), with exception of NCI-H460 cell line (TGI > 125 mu g/mL). The highest activity of the oil was observed against U251 (TGI 20.46 mu g/mL), 786.0 (TGI 20.74 mu g/mL), UACC-62 (TGI 26.98 mu g/mL) and PC-3 (TGI 27.63 mu g/mL) cell lines. The fraction rich in alpha-bisabol showed a similar activity profile. It was most active against OVCAR-3 (TGI 8.58 mu g/mL) and 786.0 (TGI 8.74 mu g/mL).
dc.description23
dc.description5
dc.descriptionSI
dc.description7
dc.description10
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherTaylor & Francis Inc
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationJournal Of Essential Oil Research
dc.relationJ. Essent. Oil Res.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectMyrcia laruotteana
dc.subjectMyrtaceae
dc.subjectessential oil composition
dc.subjectalpha-bisabolol
dc.subjectalpha-bisabolol oxide B
dc.subjectantiproliferative activity
dc.subjectAlpha-bisabolol
dc.subjectMyrtaceae
dc.titleChemical Composition and Cytotoxic Activity of Essential Oil from Myrcia laruotteana Fruits
dc.typeArtículos de revistas


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