Rapid reversal of endothelial dysfunction in hypercholesterolaemic rabbits treated with simvastatin and pravastatin

dc.creatorJorge, PAR
dc.creatorOsaki, MR
dc.creatordeAlmeida, E
dc.date1997
dc.dateDEC
dc.date2014-12-16T11:32:25Z
dc.date2015-11-26T16:28:11Z
dc.date2014-12-16T11:32:25Z
dc.date2015-11-26T16:28:11Z
dc.date.accessioned2018-03-28T23:09:11Z
dc.date.available2018-03-28T23:09:11Z
dc.identifierClinical And Experimental Pharmacology And Physiology. Blackwell Science, v. 24, n. 12, n. 948, n. 953, 1997.
dc.identifier0305-1870
dc.identifierWOS:A1997YJ03600007
dc.identifier10.1111/j.1440-1681.1997.tb02724.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58894
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58894
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58894
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269397
dc.description1. The main objective of the present study was to verify the speed with which two 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, simvastatin and pravastatin, could revert endothelial cell dysfunction in hypercholesterolaemic rabbits. An attempt was also made to correlate the plasma cholesterol level and the tissue cholesterol and malondialdehyde (MDA) contents of the aortae with the endothelium-dependent relaxation on the assumption that any endothelial dysfunction could be rapidly and partially reversed, even in the presence of relatively high serum cholesterol levels. 2. Ninety-one male New Zealand white rabbits were randomly assigned to hypercholesterolaemic (control), simvastatin or pravastatin groups. All rabbits were fed a diet supplemented with cholesterol (0.5%) and coconut oil (2%) for 8 weeks. Simvastatin (10 and 20 mg/day) and pravastatin (15 and 30 mg/day) were administered 6, 4, and 2 days before the end of the experiment. At the end of the 8th week, animals were killed and the aortae were removed for histological examination as well as for the measurement of cholesterol and MDA contents and for endothelium-dependent relaxation studies. 3. The results showed that significant improvement in endothelium-dependent relaxation was obtained only with pravastatin and only with 4 or 6 days of administration. In these cases, the cholesterol and MDA contents of the vessel wall were reduced, although no significant changes were observed in plasma total cholesterol. Higher doses of the drugs did not alter these results. 4. We conclude that pravastatin enhances endothelium-dependent relaxation when administered to cholesterol-fed rabbits, probably via an anti-oxidant action. This effect, which was observed to start on the 4th day of drug administration, may represent a new therapeutic approach for the treatment of acute coronary syndromes in hypercholesterolaemic patients.
dc.description24
dc.description12
dc.description948
dc.description953
dc.languageen
dc.publisherBlackwell Science
dc.publisherCarlton
dc.publisherAustralia
dc.relationClinical And Experimental Pharmacology And Physiology
dc.relationClin. Exp. Pharmacol. Physiol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectendothelium dysfunction
dc.subjectendothelium-dependent relaxation
dc.subjecthypercholesterolaemia
dc.subjectpravastatin
dc.subjectrabbits
dc.subjectsimvastatin
dc.subjectCoronary-artery Disease
dc.subjectCholesterol-fed Rabbits
dc.subjectLow-density Lipoprotein
dc.subjectDependent Relaxation
dc.subjectLowering Therapy
dc.subjectNitric-oxide
dc.subjectVitamin-e
dc.subjectLovastatin
dc.subjectReduction
dc.subjectImproves
dc.titleRapid reversal of endothelial dysfunction in hypercholesterolaemic rabbits treated with simvastatin and pravastatin
dc.typeArtículos de revistas


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