Artículos de revistas
Taurine Supplementation Improves Liver Glucose Control In Normal Protein And Malnourished Mice Fed A High-fat Diet
Registro en:
Molecular Nutrition And Food Research. , v. 57, n. 3, p. 423 - 434, 2013.
16134125
10.1002/mnfr.201200345
2-s2.0-84875052841
Autor
Batista T.M.
Ribeiro R.A.
da Silva P.M.R.
Camargo R.L.
Lollo P.C.B.
Boschero A.C.
Carneiro E.M.
Institución
Resumen
Scope: Poor nutrition during the perinatal period is associated with an increased risk for metabolic syndrome in adulthood. Taurine (TAU) regulates β-cell function and glucose homeo-stasis. Here, we assessed the effects of TAU supplementation upon adiposity and glucose control in malnourished mice fed a high-fat diet (HFD). Methods and results: Weaned male C57BL/6J mice were fed a control (14% protein - C) or a protein-restricted (6% protein - R) diet for 6 weeks. Afterwards, mice received or not an HFD for 8 weeks (CH and RH). Half of the HFDmice were supplemented with 5% TAU after weaning (CHT and RHT). Protein restriction led to typical malnutrition features. HFD increased body weight, adiposity, and led to hyperleptinemia, hyperphagia, glucose intolerance, and higher liver glucose output in RH and CH groups. Fasted R mice showed higher plasma adiponectin levels and increased phosphorylation of the AMP-activated protein kinase (p-AMPK) in the liver. 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