Artículos de revistas
Effect Of A Nanostructured Dendrimer-naloxonazine Complex On Endogenous Opioid Peptides μ 1 Receptor-mediated Post-ictal Antinociception
Registro en:
Nanomedicine: Nanotechnology, Biology, And Medicine. , v. 7, n. 6, p. 871 - 880, 2011.
15499634
10.1016/j.nano.2011.02.005
2-s2.0-82255191974
Autor
Felippotti T.T.
Ribeiro do Carmo D.
Paim L.L.
Stradiotto N.R.
Bicalho U.D.O.
Parada C.A.
Grillo R.
Fraceto L.F.
Coimbra N.C.
Institución
Resumen
The aim of this study was to investigate the capacity of the host dendrimer DAB-Am-16 as a drug carrier to reduce the time required for the encapsulated naloxonaxine to establish an irreversible covalent bond with μ 1-opioid receptor (resulting in a pharmacologically selective effect). The efficacy of dendrimer-naloxonazine nanocomplex (DNC) was studied in antinociception induced by convulsions elicited by intraperitoneal (IP) administration of pentylenetetrazole, and analgesia was measured by the tail-flick test. We found that animals showed increased tail-flick latencies following convulsions. Furthermore, acute pre-treatment (10 minutes) with DNC, but not with naloxonazine alone, antagonized post-ictal analgesia in comparison with control pre-treatment. However, naloxonazine treatment 24 hours before PTZ decreased post-ictal antinociception, but DNC failed to antagonize tonic-clonic seizure-induced analgesia. 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