Artículos de revistas
Novel Nucleic Acid-based Agents: Sirnas And Mirnas
Registro en:
Central Nervous System Agents In Medicinal Chemistry. , v. 8, n. 2, p. 121 - 130, 2008.
18715249
2-s2.0-45749089615
Autor
Pereira T.C.
Lopes-Cendes I.
Institución
Resumen
A novel class of therapeutic agents based on nucleic acids has emerged and shown very promising pre-clinical results, named small interfering RNAs (siRNAs) and microRNAs (miRNAs). siRNAs are small RNA duplexes capable of silencing undesired (i.e., mutant, exogenous or aberrant) gene expression with high specificity through a mechanism known as RNA interference. These agents have called special attention to neuroscience since they have been used to experimentally treat a variety of neurological diseases with distinct etiologies such as viral, prions, genetic disorders and others. siRNAs have also been used in other scenarios as: drug-receptor blockage, inhibition of pain signaling and regulation of behavior. Although in a very initial stage, miRNAs also promise novel therapeutic approaches. 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