Artículos de revistas
Physico-chemical Characterization Of Inclusion Complex Between Hydroxymethylnitrofurazone And Hydroxypropyl-β-cyclodextrin [caracterização Físico-química De Complexo De Inclusão Entre Hidroximetilnitrofurazona E Hidroxipropil-β- Ciclodextrina]
Registro en:
Quimica Nova. , v. 31, n. 2, p. 290 - 295, 2008.
1004042
10.1590/S0100-40422008000200019
2-s2.0-42149120174
Autor
Grillo R.
De Melo N.F.S.
Fraceto L.F.
Brito C.L.
Trossini G.H.G.
Menezes C.M.S.
Ferreira E.I.
Moraes C.M.
Institución
Resumen
Hydroxymethylnitrofurazone (NFOH) is a prodrug that is active against Trypanosoma cruzi. It however presents low solubility and high toxicity. Hydroxypropyl-β-cyclodextrin (HP-β-CD) can be used as a drug-delivery system for NFOH modifying its physico-chemical properties. The aim of this work is to characterize the inclusion complex between NFOH and HP-β-CD. The rate of NFOH release decreases after complexation and thermodynamic parameters from the solubility isotherm studies revealed that a stable complex is formed (ΔG° = - 1.7 kJ/mol). This study focuses on the physico-chemical characterization of a drug-delivery formulation that comes out as a potentially new therapeutic option for Chagas disease treatment. 31 2 290 295 Dias, J.C.P., (1999) Parasitologia humana e seus fundamentos gerais, , Atheneu Ed, São Paulo Andrade, Z.A., (1999) Mem. Inst. Oswaldo Cruz, 94, p. 71 Brener, Z., Andrade, Z., Barral-Netto, M.E., (2000) Trypanosoma cruzi e doença de Chagas, , Brener, Z, Zilton, A. A, Barral-Neto, M, eds, 2a ed, Guanabara Koogan: Rio de Janeiro Schmuñis, G., Em ref, A., , 3Urbina, J.A., Docampo, R., (2003) Trends Parasitol, 19, p. 495 Coura, J.R., Castro, S.L.A., (2002) Mem. Inst. Oswaldo Cruz, 97, p. 3 Gonçalves, M.F., Chung, M.C., Colli, W., Miranda, M.T.M., Ferreira, E.I., (1994) Rev. Soc. Bras. Med. Trop, 27, p. 164 Chung, M.C., (1996) Tese de Doutorado, , Universidade de São Paulo, Brasil Guido, R.V.C., Ferreira, E.I., Nassute, J.C., Varanda, E.A., Chung, M.C., (2001) Rev. Bras. Cienc. Farm, 22, p. 319 Chung, M.C., Guido, R.V.C., Martinelli, T.F., Gonçalves, M.F., Polli, M.C., Botelho, K.C.A., Varanda, E.A., Ferreira, E.I., (2003) Bioorg. Med. Chem, 11, p. 4779 Amidon, G.L., Lennernäs, H., Shah, V.P., Crison, J.R., (1995) Pharm. Res, 12, p. 413 Liu, R., (2000) Water Insoluble Drug Formulation, , Interpharm/CRC Press:New York Davis, M.E., Brewster, M.E., (2004) Nat. Rev. Drug Discovery, 3, p. 1023 de Araújo, D.R., Pinto, L.M.A., Braga, A.F.A., de Paula, E., (2003) Rev. Bras. Anestesiol, 53, p. 663 Frömming, K.H., Szejtli, J., (1994) Topics in Inclusion Science - Cyclodextrins in Pharmacy, Kluwer Academic Publishers: Hungria de Azevedo, M.B.M., Alderete, J.B., Rodriguez, J.A., Souza, A.O., Rettori, D., Torsoni, M.A., Faljoni-Alario, A., Duran, N., (2000) J. Inclusion Phenom. Macrocyclic Chem, 37, p. 93 Connors, K.A., (1997) Chem. Rev, 97, p. 1325 Ismaili, L., André, C., Nicod, L., Mozer, J.L., Millet, J., Refouvelet, B., Makki, S., Guillaume, Y.C., (2003) J. Liq. Chromatogr. Relat. Technol, 26, p. 871 Ravelet, C., Ravel, A., Grosset, C., Villet, A., Geze, A., Wouessidjewe, D., Peyrin, E., (2002) J. Liq. Chromatogr. Relat. Technol, 25, p. 421 Ravelet, C., Geze, A., Villet, A., Grosset, C., Ravel, A., Wouessidjewe, D., Peyrin, E., (2002) J. Pharm. Biomed. Anal, 29, p. 425 Paavola, A., Yliruusi, J., Kajimoto, Y., Kalso, E., Wahlström, T., Rosenberg, P., (1997) Pharm. Res, 1995, p. 12 de Araújo, D.R., Fraceto, L.F., Braga, A.F.A., de Paula, E., (2005) Rev. Bras. Anestesiol, 55, p. 316 Pinto, L.M.A., Fraceto, L.F., Santana, M.H.A., Pertinhez, T.A., Oyama Junior, S., de Paula, E., (2005) J. Pharm. Biomed. Anal, 30, p. 956 de Jesus, M.B., Pinto, L.M.A., Fraceto, L.F., Takahata, Y., Lino, A.C.S., Jaime, C., de Paula, E., (2006) J. Pharm. Biomed. Anal, 41, p. 1428 Matioli, G., (2000) Ciclodextrinas e suas aplicações em: Alimentos, fármacos, cosméticos, agricultura, biotecnologia, química analítica e produtos gerais, EDUEM, , Maringá Dodziuk, H., (2006) Cyclodextrins and their complexes, , Wiley-VCH: Germany Szejtli, J., (1996) Comprehensive Supramolecular Chemistry, , Pergamon: Oxford Másson, M., Loftsson, T., Másson, G., Stefánsson, E., (1999) J. Controlled Release, 59, p. 107 Bekers, O., Uijtendaal, E.V., Beijnen, J.H., Bult, A., Underberg, W.J.M., (1991) Drug Dev. Ind. Pharm, 17, p. 1503 Flood, K.G., Reynolds, E.R., Snow, N.H., (2000) J. Chromatogr., A, 903, p. 49 Tong, W.Q., Lach, J.L., Chin, T.F., Guillory, J.K., (1991) J. Pharm. Biomed. Anal, 9, p. 1139 Stalcup, A.M., Chang, S.S., Armstrong, D.W., Pitha, J.J., (1990) J. Chromatogr., A, 513, p. 181 Morin, N., Guillaume, Y.C., Peyrin, E., Rouland, J.C., (1998) J. Chromatogr., A, 808, p. 51 Del Valle, E.M.M., (2004) Process Biochem, 39, p. 1033 Moraes, C.M., Abrami, P., de Paula, E., Braga, A.F.A., Fraceto, L.F., (2007) Int. J. Pharm, 331, p. 99 Langerman, L., Grant, G.J., Zakowski, M., Golomb, E., Ramanathan, S., Turndorf, H., (1992) Anesth. Analg, 75, p. 900 Mowat, J.J., Mok, M.J., MacLeod, B.A., Madden, T.D., (1996) Anesthesiology, 85, p. 635 Moraes, C.M., Abrami, P., Gonçalves, M.M., Andreo-Filho, N., Fernandes, S.A., de Paula, E., Fraceto, L.F., (2007) Quim. Nova, 30, p. 777 Moraes, C.M., Abrami, P., de Araújo, D.R., Braga, A.F.A., Issa, M.G., Ferraz, H.G., de Paula, E., Fraceto, L.F., (2007) J. Incl. Phenom. Macrocycl. Chem, 57, p. 313 Moraes, C.M., Abrami, P., Braga, A.F.A., de Paula, E., Fraceto, L.F., (2007) Int. J. Pharm, 331, p. 99