Artículos de revistas
Role Of The Kinin B1 Receptor In Insulin Homeostasis And Pancreatic Islet Function
Registro en:
Biological Chemistry. , v. 387, n. 4, p. 431 - 436, 2006.
14316730
10.1515/BC.2006.057
2-s2.0-33645760265
Autor
Araujo R.C.
Mori M.A.
Merino V.F.
Bascands J.-L.
Schanstra J.P.
Zollner R.L.
Villela C.A.
Nakaie C.R.
Paiva A.C.M.
Pesquero J.L.
Bader M.
Pesquero J.B.
Institución
Resumen
Kinins are potent vasoactive peptides generated in blood and tissues by the kallikrein serine proteases. Two distinct kinin receptors have been described, one constitutive (subtype B2) and one inducible (subtype B 1), and many physiological functions have been attributed to these receptors, including glucose homeostasis and control of vascular permeability. In this study we show that mice lacking the kinin B1 receptor (B 1 -/- mice) have lower fasting plasma glucose concentrations but exhibit higher glycemia after feeding when compared to wild-type mice. B1 -/- mice also present pancreas abnormalities, characterized by fewer pancreatic islets and lower insulin content, which leads to hypoinsulinemia and reduced insulin release after a glucose load. Nevertheless, an insulin tolerance test indicated higher sensitivity in B1 -/- mice. In line with this phenotype, pancreatic vascular permeability was shown to be reduced in B1 receptor-ablated mice. 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