Artículos de revistas
Matrix remodelling and fibroblast phenotype in early lesions of human cutaneous Leishmaniasis
Fecha
1991Institución
Resumen
SUMMARY
The connective matrix participates directly in early pathological events observed in the
cutaneous lesion of leishmaniasis, due to Leishmania braziliensis guyanensis. A sample of
19 skin biopsies was examined by light and electron microscopy, in order to identify the
matrix components (collagen isotypes I to lV, elastin and membrane associated proteins)
of the dermal infiltrate, and the pattern of organization of the reparative connective
matrix.
An extensive remodelling process of apparently parasite-independent nature involves
different fibroblast sub-populations. The original organization of this immune-mediated
lesion offers a rare opportunity to study in situ the local inflammatory mediators inducing
the activation of fibroblasts and macrophages.