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Mucosal immunization with polymeric antigen BLSOmp31 using alternative delivery systems against Brucella ovis in rams
(Elsevier Science, 2019-03)
Subcellular vaccines against ovine contagious epididymitis due Brucella ovis can solve some shortcomings associated with the use of Brucella melitensis Rev 1. We have demonstrated that the parenteral immunization with ...
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
(2013-05-01)
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid ...
Desenvolvimento e caracterização de sistemas nanoestruturados para potencial administração nasal de zidovudina
(Universidade Estadual Paulista (Unesp), 2008-02-18)
A zidovudina (AZT) é o fármaco antiretroviral mais utilizado no tratamento da AIDS, porém possui baixa biodisponibilidade, pois sofre intenso metabolismo hepático. Para alcançar concentrações plasmáticas efetivas são ...
Nasal administration of liquid crystal precursor mucoadhesive vehicle as an alternative antiretroviral therapy
(2013-05-01)
The purpose of this study was to develop a mucoadhesive stimuli-sensitive drug delivery system for nasal administration of zidovudine (AZT). The system was prepared by formulating a low viscosity precursor of a liquid ...
Desenvolvimento e caracterização de sistemas nanoestruturados para potencial administração nasal de zidovudina
(Universidade Estadual Paulista (Unesp), 2008-02-18)
A zidovudina (AZT) é o fármaco antiretroviral mais utilizado no tratamento da AIDS, porém possui baixa biodisponibilidade, pois sofre intenso metabolismo hepático. Para alcançar concentrações plasmáticas efetivas são ...
Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-Blackwell, 2010-04-01)
Objectives Zidovudine is the antiretroviral drug most frequently used for the treatment of AIDS. Although its effectiveness is recognized, it undergoes extensive first-pass metabolism and exhibits poor oral bioavailability. ...
Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-Blackwell, 2010-04-01)
Objectives Zidovudine is the antiretroviral drug most frequently used for the treatment of AIDS. Although its effectiveness is recognized, it undergoes extensive first-pass metabolism and exhibits poor oral bioavailability. ...
Poly(ε-caprolactone), Eudragit® RS 100 and poly(ε-caprolactone)/Eudragit® RS 100 blend submicron particles for the sustained release of the antiretroviral efavirenz
(Elsevier, 2013-02-01)
The design of simple and scalable drug delivery systems to target the central nervous system (CNS) could represent a breakthrough in the addressment of the HIV-associated neuropathogenesis. The intranasal (i.n.) route ...
Surfactant systems for nasal zidovudine delivery: structural, rheological and mucoadhesive properties
(Wiley-blackwellMaldenEUA, 2010)