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Loss of myocardial protection against myocardial infarction in middle-aged transgenic mice overexpressing cardiac thioredoxin-1
(Impact journals, 2016-02)
Thioredoxin-1 (Trx1) protects the heart from ischemia/reperfusion (I/R) injury. Given that the age at which the first episode of coronary disease takes place has considerably decreased, life at middle-aged (MA) emerges as ...
Preischemic efferent vagal stimulation increases the size of myocardial infarction in rabbits. Role of the sympathetic nervous system
(Elsevier Ireland, 2012-03)
The vagal nerve stimulation (VNS) has been tested for the treatment of chronic heart failure in humans (Schwartz et al., 2008). However, many of the effects of parasympathetic stimulation in ischemic heart disease are still ...
Protective effects of N-(2-mercaptopropionyl)-glycine against ischemia–reperfusion injury in hypertrophied hearts
(Academic Press Inc Elsevier Science, 2013-02)
The beneficial effects of N-(2-mercaptopropionyl)-glycine (MPG) against ischemia–reperfusion injury in normotensive animals have been previously studied. Our objective was to test the action of MPG during ischemia and ...
Ischemic postconditioning reduces infarct size through the α1-Adrenergic receptor pathway
(Lippincott Williams, 2014-06)
The α1-adrenergic receptors (α1-ARs) are involved in preconditioning. Given that certain intracellular pathways seem to be shared by preconditioning and postconditioning, it is possible that postconditioning could also be ...
Early echocardiographic predictors of increased left ventricular end-diastolic pressure three months after myocardial infarction in rats
(Int Scientific Literature, Inc, 2014)
Plasmid-mediated VEGF gene transfer induces cardiomyogenesis and reduces myocardial infarct size in sheep
(Nature Publishing Group, 2006-08)
We have recently reported that in pigs with chronic myocardial ischemia heart transfection with a plasmid encoding the 165 isoform of human vascular endothelial growth factor (pVEGF165) induces an increase in the mitotic ...
Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatiory factors
(Int Scientific Literature, Inc, 2010-12-01)
Background: Although intrinsic skeletal muscle abnormalities can influence exercise intolerance during heart failure (HF), the factors responsible for muscle changes have not been elucidated. In this study we evaluated the ...
Chronic heart failure-induced skeletal muscle atrophy, necrosis, and changes in myogenic regulatiory factors
(Int Scientific Literature, Inc, 2010-12-01)
Background: Although intrinsic skeletal muscle abnormalities can influence exercise intolerance during heart failure (HF), the factors responsible for muscle changes have not been elucidated. In this study we evaluated the ...
Acute inhibition of excessive mitochondrial fission after myocardial infarction prevents long-term cardiac dysfunction
(Wiley-BlackwellOxford, 2013-10-08)
BACKGROUND:
Ischemia and reperfusion (IR) injury remains a major cause of morbidity and mortality and multiple molecular and cellular pathways have been implicated in this injury. We determined whether acute inhibition ...