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Crosstalk between DNA methylation chromatin structure
(Elsevier, 2016)
Regulation of gene expression is the result of a functional crosstalk between multiple epigenetic pathways. DNA methylation is an epigenetic mark that is typically related to gene silencing. Changes in DNA methylation are ...
High levels of circulating folate concentrations are associated with DNA methylation of tumor suppressor and repair genes p16, MLH1, and MGMT in elderly Chileans
(BIOMED Central Ltd., 2017)
Background: Changes in DNA methylation, one of the most studied epigenetic mechanisms, are considered an initial marker for early cancer detection. We evaluated how availability of dietary factors (folates and vitamin B12) ...
DNA Methylation Level of Gene SIRT1 in Ram Spermatozoa and Relationship with Fertilizing Ability According to Breed and Age
(Universidade Federal do Rio Grande do Sul, 2022)
Early detection of gastric cancer using global, genome-wide and IRF4, ELMO1, CLIP4 and MSC DNA methylation in endoscopic biopsies
(Impact Journals, 2017)
Clinically useful molecular tools to triage gastric cancer patients are not currently available. We aimed to develop a molecular tool to predict gastric cancer risk in endoscopy-driven biopsies obtained from high-risk ...
La metilación global del ADN y los niveles de homocisteína en plasma se encuentran disminuidos en pacientes con diabetes mellitus tipo 1
(Sociedad Médica de Santiago, 2015)
Background: The worldwide rise in the incidence of Type I Diabetes (T1D), and the concordance rate between monozygotic twins (50%), indicate a strong effect of the environment as an underlying factor of this disease. This ...
The methylation patterns of the IGF2 and IGF2R genes in bovine spermatozoa are not affected by flow-cytometric sex sorting
(WILEY-BLACKWELLMALDEN, 2012)
The objectives of this study were to investigate the effect of sexing by flow cytometry on the methylation patterns of the IGF2 and IGF2R genes. Frozen-thawed, unsorted, and sex-sorted sperm samples from four Nellore bulls ...
RG108 increases NANOG and OCT4 in bone marrow-derived mesenchymal cells through global changes in DNA modifications and epigenetic activation
(Public Library Science, 2018-12-03)
Human bone marrow-derived mesenchymal stem cells (hBMSCs) are important for tissue regeneration but their epigenetic regulation is not well understood. Here we investigate the ability of a non-nucleoside DNA methylation ...
Modulação dos fatores epigenéticos nos momentos iniciais da infecção pelo HIV-1 em células T CD4+ in vitro
(Universidade Federal de São Paulo (UNIFESP), 2017-03-31)
Current research trends in human immunodeficiency virus 1/acquired immune deficiency syndrome (HIV-1/AIDS) and epigenetic phenomena have been focusing on elucidating the effect of epigenetics on the viral genome and the ...