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Drug transfer into target helminth parasites
(Elsevier, 2007-03)
The pharmacokinetics of an anthelmintic drug includes the time course of drug absorption, distribution, metabolism and elimination from the host and determines the concentration of the active drug that reaches the location ...
Neutrophil-Derived MMP-8 Drives AMPK-Dependent Matrix Destruction in Human Pulmonary Tuberculosis
(Public Library of Science, 2015)
Pulmonary cavities, the hallmark of tuberculosis (TB), are characterized by high mycobacterial load and perpetuate the spread of M. tuberculosis. The mechanism of matrix destruction resulting in cavitation is not well ...
Emerging strategies on in silico drug development against COVID-19: challenges and opportunities
The importance of coronaviruses as human pathogen has been highlighted by the recent
outbreak of SARS-CoV-2 leading to the search of suitable drugs to overcome respiratory
infections caused by the virus. Due to the lack ...
Encapsulação da rifampicina em matrizes poliméricas flutuantes obtidas por liofilização a partir de metilcelulose e ftalato de hidroxipropilmetilcelulose. Avaliação da liberação in vitro
(2001-12-01)
Floating multiparticles for oral administration with different compositions were studied from a matricial polymeric system to obtain sustained release. The polymers used in the multiparticles constitution were methylceullose ...
Lipossomas: Estrategia biotecnologica para liberacao controlada e direcionamento intracelular de farmacos com efeito antimicobacteriano
(1997-01-01)
This text highlights the state of research related with the application of liposomes in the control of drug delivery and drug target to intracellular bacterial diseases, such as the tuberculosis. Liposome have several ...
Lipossomas: Estrategia biotecnologica para liberacao controlada e direcionamento intracelular de farmacos com efeito antimicobacteriano
(1997-01-01)
This text highlights the state of research related with the application of liposomes in the control of drug delivery and drug target to intracellular bacterial diseases, such as the tuberculosis. Liposome have several ...
Recent advances in micro-electro-mechanical devices for controlled drug release applications
(Frontiers Media S.A., 2020-06)
In recent years, controlled release of drugs has posed numerous challenges with the aim of optimizing parameters such as the release of the suitable quantity of drugs in the right site at the right time with the least ...
N,N-Dimethylacrylamide Hydrogels for Controlled Drug Delivery. Influence of Network Structure and Drug Solubility on the Load and Release Mechanisms
(Planta Piloto de Ingeniería Química, 2019-08)
The aim of the present work was to synthesize sustained-release hydrogels based on N,N-dimethylacrylamide (DMA) to study the effect of the polymer matrix structure and the solubility of drugs on the load and release ...
New Insights into the Mechanisms of Action of Cotinine and its Distinctive Effects from Nicotine
(Springer New York LLC, 2014)