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Experimental evidence of MAP kinase gene expression on the response of intestinal anti-inflammatory drugs
(Elsevier B. V., 2015-09-01)
The etiopathogenesis of inflammatory bowel disease (IBD) is unclear and further understanding of the mechanisms that regulate intestinal barrier integrity and function could give insight into its pathophysiology and mode ...
Saint John's wort, an herbal inducer of the cytochrome P4503A4 isoform, may alleviate symptoms of Willis-Ekbom's disease
(Faculdade de Medicina / USP, 2013-04-01)
OBJECTIVE: Certain drug classes alleviate the symptoms of Willis-Ekbom's disease, whereas others aggravate them. The pharmacological profiles of these drugs suggest that drugs that alleviate Willis-Ekbom's disease inhibit ...
Advances in drug design based on the amino acid approach: Taurine analogues for the treatment of CNS diseases
(2012-10-23)
Amino acids are well known to be an important class of compounds for the maintenance of body homeostasis and their deficit, even for the polar neuroactive aminoacids, can be controlled by supplementation. However, for the ...
Post-treatment vascular leakage and inflammatory responses around brain cysts in porcine neurocysticercosis
(Public Library of Science, 2015)
Cysticidal treatment of neurocysticercosis, an infection of humans and pig brains with Taenia solium, results in an early inflammatory response directed to cysts causing seizures and focal neurological manifestations. ...
Anthracycline-induced cardiotoxicity
(2008-10-01)
The anthracyclines constitute a group of drugs widely used for the treatment of a variety of human tumors. However, the development of irreversible cardiotoxicity has limited their use. Anthracycline-induced cardiotoxicity ...
Antiplatelet drugs reduce the immunoinflammatory response in a rat model of periodontal disease
(Wiley-Blackwell, 2014-12-01)
Background and ObjectiveAfter activation, platelets express mediators that modulate inflammation. We hypothesized that drug-induced platelet inactivation may interfere in the inflammatory process in experimental periodontal ...
Aminochrome as New Preclinical Model to Find New Pharmacological Treatment that Stop the Development of Parkinson's Disease
(Bentham Science, 2016)
The pharmacological treatment of Parkinson's disease (PD) is limited to dopamine agonists and anti-cholinergic drugs that do not stop the progress of disease. L-Dopa was introduced to the treatment in 1967; this drug is ...