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Determinação de aciclovir em plasma humano através de precipitação de proteínas por UHPLC-ESI-MS/MS: desenvolvimento, validação e aplicação em estudo de bioequivalência
(Universidade Tecnológica Federal do ParanáToledoBrasilAnálise InstrumentalUTFPR, 2019-06-07)
A sensitive ultra performance liquid chromatography-electrospray ionization-tandem mass spectrometry (UHPLC-ESI-MS/MS) method for measurements of acyclovir in plasma was developed and validated. A protein precipitation ...
Cristalização e identificação polimórfica do fármaco Cimetidina
(Universidade Tecnológica Federal do ParanáMedianeiraBrasilLicenciatura em QuímicaUTFPR, 2019-07-17)
Polymorphism is the tendency of a substance to crystallize in different forms. These may have distinct properties, such as melting point, X-ray diffraction, molecular spectrum, stability, solubility, as well as loss of ...
Conocimientos y percepciones de médicos ante los medicamentos genéricos
(2014-11-13)
Se realizó un estudio para establecer los factores que influyen en el conocimiento y percepción de los medicamentos genéricos en una muestra de médicos en Bogotá. Metodología: el trabajo se realizó en tres fases: i) ...
Importancia y fundamentación del sistema de clasificación biofarmacéutico, como base de la exención de estudios de biodisponibilidad y bioequivalencia in vivo
(Revista Colombiana de Ciencias Químico Farmacéuticas, 2008)
El Sistema de Clasificación Biofarmacéutica (SCB), publicado por Gordon Amidon y cols. en 1995, se basa en un sólido fundamento científico para clasificar un fármaco considerando los parámetros de solubilidad y permeabilidad, ...
Should licking behavior be considered in the bioavailability evaluation of transdermal products?
(Wiley Blackwell Publishing, Inc, 2012-04)
Antiparasitic drugs, and especially macrocyclic lactones (MLs), are often formulated as pour-on products because of their ease of administration, convenience, and reduction of stress in treated animals. However, because ...
Biowaiver monographs for immediate release solid oral dosage forms: Ciprofloxacin hydrochloride
(John Wiley & Sons Inc, 2011-01)
Literature data relevant to the decision to allow a waiver of in vivo bioequivalence (BE) testing for the approval of new multisource and reformulated immediate release (IR) solid oral dosage forms containing ciprofloxacin ...
Drug distribution
(Springer, 2018)
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. ...
A Comparative Analysis of Dissolution Profiles of Furosemide Tablets Available in the Argentinean Market (Part 2)
(BP International, 2021)
The rate and the extent of drug dissolution and its absorption depend on the characteristics of the active pharmaceutical ingredient (API) as well as the dosage form properties. In this work dissolution profiles of furosemide ...
Novel formulation and drug delivery strategies for the treatment of pediatric poverty-related diseases
(Informa Healthcare, 2012-03)
INTRODUCTION: Due to a lack of approved drugs and formulations, children represent the most vulnerable patients. Magistral, unlicensed formulations obtained by the manipulation of solid forms should undergo clinical ...
Drug Metabolism
(Springer, 2018)
Absorption, Distribution, Metabolism and Excretion (ADME) processes and their relationship with the design of dosage forms and the success of pharmacotherapy form the basis of this upper level undergraduate/graduate textbook. ...