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Alterações do gene TP53 na mucosa esofágica de pacientes com carcinoma epidermóide do esôfago
(Universidade Federal de Santa MariaBrasilFarmáciaUFSMPrograma de Pós-Graduação em Ciências FarmacêuticasCentro de Ciências da Saúde, 2016-08-22)
Esophageal cancer is a tumor with a higher incidence in males, and it is highly fatal. Epidemiological
data points out to consumption of tobacco and alcohol and the exposition to polycyclic aromatic
hydrocarbon are the ...
DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
(Assoc Bras Divulg Cientifica, 2015-06-01)
Li-Fraumeni syndrome (LFS) is a rare, autosomal dominant, hereditary cancer predisposition disorder. In Brazil, the p.R337H TP53 founder mutation causes the variant form of LFS, Li-Fraumeni-like syndrome. The occurrence ...
Cytotoxic and toxicogenomic effects of silibinin in bladder cancer cells with different TP53 status
(Indian Acad Sciences, 2017-03-01)
Silibinin is a natural phenol found in the seeds of the milk thistle plant. Recent data have shown its effectiveness for preventing/treating bladder tumours. Therefore, in this study we investigated the cytotoxic and ...
Alterations of the TP53 Gene in Gastric and Esophageal Carcinogenesis
(Hindawi Publishing Corporation, 2014)
DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
(Assoc Bras Divulg Cientifica, 2015)
Polymorphisms and DNA methylation of gene TP53 associated with extra-axial brain tumors
(FUNPEC-EDITORA, 2009)
The p53 tumor suppressor gene is the most frequently mutated gene in human cancer; this gene is mutated in up to 50% of human tumors. It has a critical role in the cell cycle, apoptosis and cell senescence, and it participates ...
DNA methylation patterns of candidate genes regulated by thymine DNA glycosylase in patients with TP53 germline mutations
(Assoc Bras Divulg Cientifica, 2015)