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Intracoronary infusion of a combination of bone marrow-derived stem cells in dogs
(2010)
BACKGROUND: Infusion of diverse types of bone marrow cells, as a source of endothelial progenitor cells (EPCs), into the ischemic myocardium is emerging as a promising therapy for coronary ischemia, probably mediated by ...
Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection
(2008)
In addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T
(Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, ...
Role of glycosylation in hypoxia-driven cell migration and invasion
(NLM (Medline), 2019)
Hypoxia, a common condition of the tumor microenvironment, induces changes in the proteome of cancer cells, mainly via HIF-1, a transcription factor conformed by a constitutively expressed β-subunit and an oxygen-regulated ...
Mesenchymal stem cells instruct oligodendrogenic fate decision on adult neural stem cells
(ALPHAMED PRESS, 2006-10)
Adult stem cells reside in different tissues and organs of the adult organism. Among these cells are MSCs that are located in the adult bone marrow and NSCs that exist in the adult central nervous system (CNS). In ...
Engineering CHO cells galactose metabolism to reduce lactate synthesis
(Springer Netherlands, 2019)
Objective: Over-express galactokinase (Galk1) in tissue plasminogen activator (tPA) producing CHO cells as a potential strategy to improve cell growth and product synthesis. Results: tPA producing CHO cells were transfected ...
The compound 14-keto stypodiol diacetate from the algae Stypopodium flabelliforme inhibits microtubules and cell proliferation in DU-145 human prostatic cells
(1998)
We investigated the effects of the drug 14-keto-stypodiol diacetate (SDA) extracted from the seaweed product Stypopodium flabelliforme, in inhibiting the cell growth and tumor invasive behavior of DU-145 human prostate ...
Dexamethasone turns tumor antigen-presenting cells into tolerogenic dendritic cells with T cell inhibitory functions
(Elsevier GmbH, 2019)
Background: Dendritic cells (DCs) are usually immunogenic, but they are also capable of inducing tolerance under anti-inflammatory conditions. Immunotherapy based on autologous DCs loaded with an allogeneic melanoma cell ...
Comparative metabolic analysis of CHO cell clones obtained through cell engineering, for IgG productivity, growth and cell longevity
(Plos one, 2015)
Cell engineering has been used to improve animal cells' central carbon metabolism. Due to the central carbon metabolism's inefficiency and limiting input of carbons into the TCA cycle, key reactions belonging to these ...
Interleukin 10 decreases MICA expression on melanoma cell surface
(2011)
Natural-killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC)
class I chain-related proteins (MIC) and UL16-binding proteins (ULBP). It is regarded as a ...