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Mostrando ítems 131-140 de 276
Activation of D1/D5 Dopamine Receptors Protects Neurons from Synapse Dysfunction Induced by Amyloid-beta Oligomers
(Amer Soc Biochemistry Molecular Biology Inc, 2011-02-04)
Soluble oligomers of the amyloid-beta peptide (A beta Os) accumulate in the brains of Alzheimer disease (AD) patients and are implicated in synapse failure and early memory loss in AD. A beta Os have been shown to impact ...
Estratégias de inovação em bibliotecas universitárias: foco nas gerações y e z
(LondrinaBrasil, 2017)
The purpose of this article is to analyze innovation strategies in the context of Academic Libraries (ALs). The objectives were to investigate whether ALs innovate, identify which factors influence innovation in these ...
Studies on the Roles of Boron in Growth and Sugar-Transport Processes of SugarcaneTítulo en español.
(University of Puerto Rico Mayagüez Campus Agricultural Experiment Station, 1973)
The X-linked inhibitor of apoptosis regulates long-term depression and learning rate
(Federation of American Societies for Experimental Biology, 2016-09)
Hippocampal long-term depression (LTD) is an active form of synaptic plasticity that is necessary for consolidation of spatialmemory, contextual fearmemory, and novelty acquisition. Recent studies have shown that caspases ...
Modulation of extrasynaptic GABAergic receptor activity influences glutamate release and neuronal survival following excitotoxic damage to mouse spinal cord neurons
(Pergamon-Elsevier Science Ltd, 2019-09)
Excitotoxic levels of released glutamate trigger a cascade of deleterious cellular events leading to delayed neuronal death. This phenomenon implies extensive dysregulation in the balance between network excitation and ...
Expressão de GABA e plasticidade do fenótipo neuroquímico e morfológico de células da Zona Subventricular pós-natal
(Brasil, 2008)
The subventricular zone (SVZ) is proliferative epithelium that continuously gives rise to new neurons in postnatal and adult mammals. The neurons generated in the SVZ migrate through the rostral migratory stream (RMS) where ...
Measurement of cystic fibrosis transmembrane conductance regulator activity using fluorescence spectrophotometry
(Elsevier, 2011)
Abstract: Cystic fibrosis (CF) is a frequent autosomal recessive disease caused by mutations that impair the CF
transmembrane conductance regulator (CFTR) protein function. CFTR is a chloride channel activated by
cyclic ...
Calcium release by ryanodine receptors mediates hydrogen peroxide-induced activation of ERK and CREB phosphorylation in N2a cells and hippocampal neurons
(2007)
Hydrogen peroxide, which stimulates ERK phosphorylation and synaptic plasticity in hippocampal neurons, has also been shown to stimulate calcium release in muscle cells by promoting ryanodine receptor redox modification ...
Extracellular adenosine promotes cell migration/invasion of Glioblastoma Stem-like Cells through A 3 Adenosine Receptor activation under hypoxia
(Elsevier Ireland Ltd, 2019)
Glioblastoma (GBM) is the brain tumor with the worst prognosis composed of a cell subpopulation called Glioblastoma Stem-like Cells (GSCs) responsible for tumor recurrence mediated by cell invasion. GSCs persist in a hypoxic ...
Cultura de condrócitos em arcabouço tridimensional: hidrogel de alginato
(Sociedade Brasileira de Ortopedia e Traumatologia, 2009-01-01)
OBJETIVOS: O presente estudo teve como objetivo cultivar condrócitos retirados da articulação do joelho de coelhos encapsulados em hidrogel de alginato (HA) e caracterizar a produção de matriz extracelular (ECM). MÉTODOS: ...