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Current advances in antitubercular drug discovery: potent prototypes and new targets
(Bentham Science Publishers, 2015)
Tuberculosis (TB) is an infectious disease caused by bacterium of the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization aims to substantially reduce the number of cases in the ...
Low-cost diagnostic test for susceptible and drug-resistant tuberculosis in rural Malawi
(African Online Scientific Information Systems, 2018)
Background: Rural settings where molecular tuberculosis diagnostics are not currently available need easy-to-use tests that do not require additional processing or equipment. While acid-fast bacilli (AFB) smear is the most ...
Tuberculosis genetic epidemiology: A latin american perspective
(MDPI, 2019)
There are an estimated 10 million new cases of tuberculosis worldwide annually, with 282,000 new or relapsed cases each year reported from the Americas. With improvements in genome sequencing technology, it is now possible ...
Isoniazid Preventive Therapy in Contacts of Multidrug-resistant Tuberculosis.
(American Thoracic Society, 2020)
RATIONALE: The World Health Organization recommends the use of isoniazid alone or in combination with rifapentine to treat latent tuberculosis infection. The recent rise of drug-resistant tuberculosis has complicated the ...
Evaluation of the tuberculosis culture color plate test for rapid detection of drug susceptible and drug-resistant Mycobacterium tuberculosis in a resource-limited setting, Addis Ababa, Ethiopia
(Public Library of Science, 2019)
Timely diagnosis of tuberculosis (TB) is limited in Ethiopia. We evaluated the performance of a low technology, thin layer agar, Mycobacterium tuberculosis (M.tb) culture color plate (TB-CX) test with concurrent drug ...
Reported cases of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis in Salvador, Brazil
(Sociedade Brasileira de Medicina Tropical, 2017)
Cough dynamics in adults receiving tuberculosis treatment
(Public Library of Science, 2020)
Cough is a characteristic symptom of tuberculosis, is the main cause of transmission, and is used to assess treatment response. We aimed to identify the best measure of cough severity and characterize changes during initial ...
Genomic signatures of pre-resistance in Mycobacterium tuberculosis.
(Springer Nature, 2021)
Recent advances in bacterial whole-genome sequencing have resulted in a comprehensive catalog of antibiotic resistance genomic signatures in Mycobacterium tuberculosis. With a view to pre-empt the emergence of resistance, ...