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DM-1, sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate: a curcumin analog with a synergic effect in combination with paclitaxel in breast cancer treatment
(SPRINGERDORDRECHT, 2013-08-02)
This paper describes a new method for the preparation of sodium 4-[5-(4-hydroxy-3-methoxyphenyl)-3-oxo-penta-1,4-dienyl]-2-methoxy-phenolate, DM-1, and 3-oxo-penta-1,4-dienyl-bis (2-methoxy-phenolate), DM-2. The aim of ...
Paclitaxel associated with cholesterol-rich nanoemulsions promotes atherosclerosis regression in the rabbit
(ELSEVIER IRELAND LTD, 2008)
A cholesterol-rich nanoemulsion (LDE) that resembles LDL binds to the LDL receptors and after injection into the blood stream may concentrate in cells with LDL receptor overexpression, as occurs in neoplasias and other ...
Resistance to cisplatin and paclitaxel does not affect the sensitivity of human ovarian cancer cells to antiprogestin- induced cytotoxicity
(BioMed Central, 2014-04)
BACKGROUND: Antiprogestin compounds have been shown to be effective in blocking the growth of ovarian cancer cells of different genetic backgrounds. Herein we studied the anti-ovarian cancer effect of a series of antiprogestins ...
Murine erythropoietic impairment induced by paclitaxel: Interactions of GATA-1 and erythroid Krüppel-like transcription factors, apoptotic related proteins and erythropoietin receptor
(Elsevier Science, 2010-06)
Paclitaxel, an antitumoral drug, was used in a single dose (29mg/kg i.p.) as an injury agent for inducing transient suppression of hematopoiesis in a murine experimental model during 10days. The aim of this study focuses ...
Muscarinic activation enhances the anti-proliferative effect of paclitaxel in murine breast tumor cells
(Bentham Science Publishers, 2013-10)
Muscarinic acetylcholine receptors (mAChR) are expressed in cells without nervous origin. mAChR are up-regulated in tumor cells and their stimulation can modulate tumor growth. In this work we investigated the ability of ...
Paclitaxel delivery system based on poly(lactide-co-glycolide) microparticles and chitosan thermo-sensitive gel for mammary adenocarcinoma treatment
(Pharmaceutical Press-Royal Pharmaceutical Society Great Britian, 2018-11)
Objectives: To evaluate the combination of more than one release system in the same formulation as a useful strategy to achieve paclitaxel delivery in a more sustained and controlled manner. Methods: The present study deals ...
Systèmes dispersés pour l'administration orale du paclitaxel à base de microémulsion et de nanocapsules mucoadhésives contenant de l'huile de copaiba
(Universidade Federal do Rio Grande do NorteBrasilUFRNPROGRAMA DE PÓS-GRADUAÇÃO EM BIOTECNOLOGIA, 2015-03-05)