Now showing items 21-30 of 6602
Folate biosynthesis pathway: mechanisms and insights into drug design for infectious diseases
(Future Sci Ltd, 2018-04-01)
Folate pathway is a key target for the development of new drugs against infectious diseases since the discovery of sulfa drugs and trimethoprim. The knowledge about this pathway has increased in the last years and the ...
A rabbit model demonstrates the influence of cartilage thickness on intra-articular drug delivery and retention within cartilage
(Orthopaedic Research Society. Published by Wiley Periodicals, Inc., 2015)
For evaluation of new approaches to drug delivery into cartilage, the choice of an animal model is critically important. Since cartilage thickness varies with animal size, different levels of drug uptake, transport and ...
Pharmacokinetic Profile of A New Diclofenac Prodrug without Gastroulcerogenic Effect
Gastrotoxicity is a major problem for long-term therapy with non-steroidal anti-inflammatory drugs (NSAIDs). DICCIC (1-(2,6-dichlorophenyl)indolin-2-one) is a new diclofenac prodrug, which has proven anti-inflammatory ...
POTENTIAL MOLECULAR TARGETS FOR ANTITUBERCULOSIS DRUG DISCOVERY
(Soc Brasileira Quimica, 2017-06-01)
Tuberculosis (TB) is an infectious disease caused by mycobacteria from the Mycobacterium genus, mainly by Mycobacterium tuberculosis (MTB). The World Health Organization (WHO) aims to reduce the number of TB cases worldwide ...
A New Methodology to Create Polymeric Nanocarriers Containing Hydrophilic Low Molecular-Weight Drugs: A Green Strategy Providing a Very High Drug Loading
(American Chemical Society, 2019)
To date, a large number of active molecules are hydrophilic and aromatic low molecular-weight drugs (HALMD). Unfortunately, the low capacity of these molecules to interact with excipients and the fast release when a ...
Current advances in antitubercular drug discovery: potent prototypes and new targets
(Bentham Science Publishers, 2015)
New antimycobacterial agents in the pre-clinical phase or beyond: recent advances in patent literature (2001–2016)
Introduction: Tuberculosis, an infectious disease, has caused more deaths worldwide than any other single infectious disease, killing more than 1.5 million people each year; equating to 4,100 deaths a day. In the past ...