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Suppression of neuroinflammation in forebrain-specific Cdk5 conditional knockout mice by PPARγ agonist improves neuronal loss and early lethality
(BioMed Central Ltd., 2014)
Background: Cyclin-dependent kinase 5 (Cdk5) is essential for brain development and function, and its deregulated expression is implicated in some of neurodegenerative diseases. We reported earlier that the forebrain-specific ...
Dancing with glia: The role of astrocytes, microglia and oligodendrocytes and their relation with neurons in neuroinflammation and aging
(Biomedscis, 2020-12-03)
This review provides an original overview of glial cells functions on the central nervous system and their relationship withneuroinflammation. We decided to correlate astrocytes, microglia and oligodendrocytes functions ...
Outside in: Unraveling the role of neuroinflammation in the progression of Parkinson's disease
(Frontiers Media S.A., 2018)
Copyright © 2018 Troncoso-Escudero, Parra, Nassif and Vidal. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other ...
Opposing roles of interferon-gamma on cells of the central nervous system in autoimmune neuroinflammation
(Frontiers Media, 2015)
Multiple sclerosis (MS) is the principal cause of autoimmune neuroinflammation in humans, and its animal model, experimental autoimmune encephalomyelitis (EAE), is widely used to gain insight about their immunopathological ...
Neuroinflammation in the pathogenesis of Alzheimer's disease. A rational framework for the search of novel therapeutic approaches
(Frontiers Research Foundation, 2014)
Alzheimer disease (AD) is the most common cause of dementia in people over 60 years
old. The molecular and cellular alterations that trigger this disease are still diffuse, one
of the reasons for the delay in finding an ...
Dopamine receptor D3 signalling in astrocytes promotes neuroinflammation
(Facultad de Medicina y Ciencia, 2019)
Background Neuroinflammation constitutes a pathogenic process leading to neurodegeneration in several disorders, including Alzheimer's disease, Parkinson's disease (PD) and sepsis. Despite microglial cells being the central ...