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Transcription-associated DNA DSBs activate p53 during hiPSC-based neurogenesis
(2022-12)
Neurons are overproduced during cerebral cortical development. Neural progenitor cells (NPCs) divide rapidly and incur frequent DNA double-strand breaks (DSBs) throughout cortical neurogenesis. Although half of the neurons ...
Memória espacial e neuroquímica do hipocampo em modelo animal de autismo
(Universidade Estadual Paulista (Unesp), 2018-05-25)
Reações imunes geradas no organismo materno durante o período gestacional podem provocar alterações no desenvolvimento do feto. O LPS, endotoxina lipopolissacarídea presente na parede das bactérias gram-negativas, é capaz ...
Avaliação da espessura cortical e volume de estruturas subcorticais associados ao fator neurotrófico derivado do cérebro (BDNF) em uma coorte de alto risco de desenvolvimento de transtornos psiquiátricos durante a infância e adolescência
(Universidade Federal de São Paulo (UNIFESP), 2018-10-22)
Background: The Brain Derived Neurotrophic Factor (BDNF) is a neurotrophin that
plays a key role in synaptic plasticity and transmission. The BDNF Val66Met
polymorphism (rs6265) has been associated with neuropsychiatric ...
Neurodevelopment alterations in preschool children with a history of prematurity: a cross-sectional studyAlteraciones en el neurodesarrollo en preescolares con antecedente de prematurez: un estudio de corteAlterações no neuro desenvolvimento em pré-escolares com antecedente de prematuridade: um estudo de corte
(Universidad Militar Nueva Granada, 2019)
Heparin Activates Wnt Signaling for Neuronal Morphogenesis
(2008)
Wnt factors are secreted ligands that affect different aspects of the nervous system behavior like neurodevelopment, synaptogenesis and neurodegeneration. In different model systems, Wnt signaling has been demonstrated to ...
Gestational hypothyroidism in mice makes female offspring more resistant to pneumococcal pneumonia.
(2014)
Gestational hypothyroidism affects fetus neurodevelopment and leads to cognitive deficiencies. In rodents, this condition also affects the central nervous system and produces differences in the amount and type of immune ...