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Role of PI3K in myocardial ischaemic preconditioning: mapping pro-survival cascades at the trigger phase and at reperfusion
(Wiley, 2018)
The Reperfusion Injury Salvage Kinase (RISK) pathway is considered the main pro-survival kinase cascade mediating the ischaemic preconditioning (IPC) cardioprotective effect. To assess the role of PI3K-Akt, its negative ...
Molecular Basis of Cardioprotective Effect of Antioxidant Vitamins in Myocardial Infarction
(Hindawi, 2013)
Acute myocardial infarction (AMI) is the leading cause of mortality worldwide.Major advances in the treatment of acute coronary
syndromes andmyocardial infarction, using cardiologic interventions, such as thrombolysis or ...
Acute treatment with copoazú fermented extract ameliorates myocardial ischemia-reperfusion injury via eNOS activation
(Elsevier Ltd, 2017-07)
Our aim was to examine the effects of aqueous extracts of fermented (CFE) and non-fermented (CNFE) ¨copoazú¨ (fruit of Theobroma grandiflorum) seeds against ischemia-reperfusion injury. Isolated rat hearts were submitted ...
Comparative experimental study of myocardial protection with crystalloid solutions for heart transplantation
(SOC BRASIL CIRURGIA CARDIOVASCSAO PAULO SP, 2012)
Background: There is a growing need to improve myocardial protection, which will lead to better performance of cardiac operations and reduce morbidity and mortality. Therefore, the objective of this study was to compare ...
Aerobic exercise training induces superior cardioprotection following myocardial ischemia reperfusion injury than a single aerobic exercise session in rats
(Universidade Estadual Paulista, 2017)
Investigations on the new free radical scavenger polynitroxyl-albumin to prevent ischemia and reperfusion injury after orthotopic heart transplantation in the pig model
(Elsevier B.V., 2001-03-01)
Objective: Nitroxides have strong antioxidant capacity but their effectiveness is limited by their rapid intracellular inactivation. Poly nitroxyl-Albumin (PNA) is capable of regenerating inactivated nitroxide. We tested ...
Targeting the Endothelium to Achieve Cardioprotection
(Frontiers Media, 2021)
Despite considerable improvements in the treatment of myocardial infarction, it is still a highly prevalent disease worldwide. Novel therapeutic strategies to limit infarct size are required to protect myocardial function ...
The role of magnesium in the endothelial dysfunction caused by global ischemia followed by reperfusion: in vitro study of canine coronary arteries
(Taylor & Francis AsOsloNoruega, 2003)
Communication between cardiomyocytes and fibroblasts during cardiac ischemia/reperfusion and remodeling: roles of TGF-beta, CTGF, the Renin Angiotensin Axis, and non-coding RNA molecules
(Frontiers Media, 2021)
Communication between cells is a foundational concept for understanding the physiology and pathology of biological systems. Paracrine/autocrine signaling, direct cell-to-cell interplay, and extracellular matrix interactions ...
Isoespintanol, a monoterpene isolated from oxandra cf xylopioides, ameliorates the myocardial ischemia-reperfusion injury by AKT/PKCε/eNOS-dependent pathways
(Springer Verlag Berlín, 2019-11-27)
Purpose To determine the actions of isoespintanol (Isoesp) on post-ischemic myocardial and mitochondrial alterations. Methods Hearts removed from Wistar rats were perfused by 20 min. After this period, the coronary flow ...