Now showing items 31-40 of 2444
Molecular structures and preferred conformations of stabilized keto diester phosphonium ylides
Triphenylphosphonium ylidic keto diesters with a nonylidic ester group, Ph3PC(CO2CH2CH3)COCO 2CH2CH3, 1, and Ph3PC(CO 2CH2CH3)COCH2CO2CH 2CH3, 2, have the keto group syn and the ylidic ester acyl group anti to phosphorus. ...
Alzheimer's and prion disease as disorders of protein conformation: Implications for the design of novel therapeutic approaches
Several lines of evidence suggest that a defective protein folding is a central event in both Alzheimer's and prion disease. Although the two disorders are very different clinically, neuropathologically, and biochemically, ...
Steric constraints as folding coadjuvant
Through the analyses of the Miyazawa-Jernigan matrix it has been shown that the hydrophobic effect generates the dominant driving force for protein folding. By using both lattice and off-lattice models, it is shown that ...
A H-1 NMR and molecular modelling investigation of diastereotopic methylene hydrogen atoms
(John Wiley & Sons LtdW SussexInglaterra, 2002)