Now showing items 41-50 of 299
Obesity increases mitogen-activated protein kinase phosphatase-3 levels in the hypothalamus of mice
Mitogen-activated Protein Kinase Phosphatase 3 (MKP-3) has been involved in the negative regulation of insulin signaling. The absence of MKP-3 is also associated with reduced adiposity, increased energy expenditure and ...
Sab is differentially expressed in the brain and affects neuronal activity
(Elsevier Science, 2017-09)
Sab (SH3 binding protein 5 or SH3BP5) is a mitochondrial scaffold protein involved in signaling associated with mitochondrial dysfunction and apoptosis; furthermore, Sab is a crucial signaling platform for neurodegenerative ...
Modulation of host cell signaling pathways as a therapeutic approach in periodontal disease
(Faculdade De Odontologia De Bauru - USP, 2012)
Recently, new treatment approaches have been developed to target the host component of periodontal disease. This review aims at providing updated information on host-modulating therapies, focusing on treatment strategies ...
Treatment with galectin-1 eye drops regulates mast cell degranulation and attenuates the severity of conjunctivitis
Galectin-1 (Gal-1) is a β-galactoside-binding protein with diverse biological activities in the pathogenesis of inflammation, however the mechanisms by which Gal-1 modulates cellular responses in allergic inflammatory ...
Treatment with a p38 MAPK inhibitor attenuates cisplatin nephrotoxicity starting after the beginning of renal damage
(PERGAMON-ELSEVIER SCIENCE LTD, 2009)
Aims: Cisplatin (CP) promotes increased production of reactive oxygen species, which can activate p38 mitogen activated protein kinases (p38 MAPKs) leading to apoptosis and increased expression of proinflammatory mediators ...
Phosphorylation of Mitogen-Activated Protein Kinases Contributes to Interferon γ Production in Response to Mycobacterium tuberculosis
(Oxford University Press, 2012-12)
Immune control of Mycobacterium tuberculosis depends on interferon γ (IFN-γ)–producing CD4+ lymphocytes. Previous studies have shown that T cells from patients with tuberculosis produce less IFN-γ, compared with healthy ...