Buscar
Mostrando ítems 51-60 de 2393
Estudio de la función de NUAK1 como regulador de la actividad mitocondrial en líneas celulares de cáncer.Study of NUAK1 as regulator of mitochondrial activity in cancer cell lines.
(2019)
NUAK1 is a serine/threonine kinase member of AMPK catalytic subunit family and, localizes in cytosolic and nuclear subcellular compartments, according to the cancer cell line. NUAK1 is overexpressed in multiple cancers and ...
Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics
(Frontiers Media S.A., 2020-11-23)
Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of ∼2 × 1011 cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid progenitors, ...
Mitochondrial dynamics, mitophagy and cardiovascular disease
(WILEY-BLACKWELL, 2016)
Cardiac hypertrophy is often initiated as an adaptive response to haemodynamic stress or myocardial injury, and allows the heart to meet an increased demand for oxygen. Although initially beneficial, hypertrophy can ...
Fatal infantile mitochondrial encephalomyopathy, hypertrophic cardiomyopathy and optic atrophy associated with a homozygous OPA1 mutation
(2016)
Background Infantile-onset encephalopathy and hypertrophic cardiomyopathy caused by mitochondrial oxidative phosphorylation defects are genetically heterogeneous with defects involving both the mitochondrial and nuclear ...
PDGF-BB Preserves Mitochondrial Morphology, Attenuates ROS Production, and Upregulates Neuroglobin in an Astrocytic Model Under Rotenone Insult
(2018-04-01)
Platelet-derived growth factor, subtype BB (PDGF-BB) is a mitogenic growth factor produced in different cell types such as platelets, fibroblasts, neurons, and astrocytes. Previous reports have shown that different PDGF ...
Mitochondrial sequence data and Dipsacales phylogeny: Mixed models, partitioned Bayesian analyses, and model selection
(ACADEMIC PRESS INC ELSEVIER SCIENCE, 2008)
Phylogenetic analyses of chloroplast DNA sequences, morphology, and combined data have provided consistent support for many of the major branches within the angiosperm, clade Dipsacales. Here we use sequences from three ...
Cytotoxicity of phenothiazine derivatives associated with mitochondrial dysfunction: A structure-activity investigation
(Elsevier B.V., 2015-04-01)
Phenothiazine derivatives are neuroleptic drugs used in the treatment of schizophrenia and anxiety. Several side effects are described for these drugs, including hepatotoxicity, which may be related to their cytotoxic ...
Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery
(Elsevier, 2014-09)
Mitochondrial biogenesis emerges as a compensatory mechanism involved in the recovery process in endotoxemia and sepsis. The aim of this work was to analyze the time course of the cardiac mitochondrial biogenesis process ...
Physical training reverses changes in hepatic mitochondrial diameter of Alloxan-induced diabetic rats
(Inst Israelita Ensino & Pesquisa Albert Einstein, 2018-07-01)
Objective: To investigate the effects of physical training on metabolic and morphological parameters of diabetic rats. Methods: Wistar rats were randomized into four groups: sedentary control, trained control, sedentary ...