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Metabolic syndrome and antipsychotics: The role of mitochondrial fission/fusion imbalance
(Frontiers Media SA, 2018)
Second-generation antipsychotics (SGAs) are known to increase cardiovascular risk through several physiological mechanisms, including insulin resistance, hepatic steatosis, hyperphagia, and accelerated weight gain. There ...
Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes
(Elsevier Inc., 2014)
© 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
Erythroid Differentiation and Heme Biosynthesis Are Dependent on a Shift in the Balance of Mitochondrial Fusion and Fission Dynamics
(Frontiers Media S.A., 2020-11)
Erythropoiesis is the most robust cellular differentiation and proliferation system, with a production of similar to 2 x 10(11) cells per day. In this fine-tuned process, the hematopoietic stem cells (HSCs) generate erythroid ...
Emerging role of mitophagy in cardiovascular physiology and pathology
(Elsevier, 2020)
Healthy mitochondrial function is imperative for most tissues, but especially those with a high energy demand. Robust evidence linking mitochondrial dysfunction with cardiovascular disease has demonstrated that mitochondrial ...
Ryanodine receptor-mediated Ca2+ release underlies iron-induced mitochondrial fission and stimulates mitochondrial Ca2+ uptake in primary hippocampal neurons
(Frontiers Research Foundation, 2014)
Mounting evidence indicates that iron accumulation impairs brain function. We have reported previously that addition of sub-lethal concentrations of iron to primary hippocampal neurons produces Ca2+ signals and promotes ...
Drp1 loss-of-function reduces cardiomyocyte oxygen dependence protecting the heart from ischemia-reperfusion injury
(Lippincott Williams and Wilkins, 2014)
Mitochondria are key organelles for ATP production in cardiomyocytes, which is regulated by processes of fission and fusion. We hypothesized that the mitochondria fusion protein dynamin-related protein 1 (Drp1) inhibition, ...
Mitochondrial network complexity emerges from fission/fusion dynamics
(Nature Publishing Group, 2018-12)
Mitochondrial networks exhibit a variety of complex behaviors, including coordinated cell-wide oscillations of energy states as well as a phase transition (depolarization) in response to oxidative stress. Since functional ...
A Novel Mechanism Causing Imbalance Of Mitochondrial Fusion And Fission In Human Myopathies
(2018)
Mitochondrial dynamics play an important role in cellular homeostasis and a variety of human diseases are linked to its dysregulated function. Here, we describe a 15-year-old boy with a novel disease caused by altered ...