Background: Currently, 13-cis-retinoic acid (13-cis-RA) is the most effective therapy for acne. Isotretinoin, a first-generation synthetic 13-cis-RA compound, is associated with numerous adverse effects. To investigate the ...

One of the most often used strategies to study the physiopathological alterations caused by coronary occlusion is the use of the experimental infarction model in rats. Among other factors, this is due to the similarities ...

Background: Although skeletal muscle atrophy and changes in myosin heavy chain (MyHC) isoforms have often been observed during heart failure, their pathophysiological mechanisms are not completely defined. In this study ...

Cardiac or ventricular remodeling is characterized by molecular, cellular, and interstitial alterations that lead to changes in heart size, mass, geometry and function in response to a given insult. Currently, tobacco smoke ...

The aim of this study was to evaluate changes in heart rate, cardiac size and muscle mass in healthy dogs during an aerobic training program. Dogs (n=9) had 10-min treadmill sessions twice a week for 12 weeks. Data were ...

This study was aimed to evaluate the influence of vitamin D (VD) deficiency on cardiac metabolism, morphology, and function. Thus, we investigated the relationship of these changes with the length of the nutrient restriction. ...

Purpose: To analyse the effect of early (<24 h) administration of lisinopril on ventricular remodeling and mortality after myocardial infarction (MI) in rats. Methods: Wistar rats weighing 200-250 g were submitted to ...