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BRDT is an essential epigenetic regulator for proper chromatin organization, silencing of sex chromosomes and crossover formation in male meiosis
(Public Library Science, 2018)
The double bromodomain and extra-terminal domain (BET) proteins are critical epigenetic
readers that bind to acetylated histones in chromatin and regulate transcriptional activity
and modulate changes in chromatin structure ...
Slit neuronal secretion coordinates optic lobe morphogenesis in Drosophila
(Elsevier, 2020)
The complexity of the nervous system requires the coordination of multiple cellular processes during development. Among them, we find boundary formation, axon guidance, cell migration and cell segregation. Understanding ...
Epigenetic Reader BRD4 (Bromodomain-Containing Protein 4) Governs Nucleus-Encoded Mitochondrial Transcriptome to Regulate Cardiac Function
(Lippincott Williams & Wilkins, 2020)
BACKGROUND: BET (bromodomain and extraterminal) epigenetic reader proteins, in particular BRD4 (bromodomain-containing protein 4), have emerged as potential therapeutic targets in a number of pathological conditions, ...
FoxO1-Dio2 signaling axis governs cardiomyocyte thyroid hormone metabolism and hypertrophic growth
(Nature, 2020)
Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
Chemical dissection of the APC repeat 3 multistep phosphorylation by the concerted action of protein kinases CK1 and GSK3
(2007)
A crucial event in machinery controlled by Wnt signaling is the association of β-catenin with the adenomatous polyposis coli (APC) protein, which is essential for the degradation of β-catenin and requires the multiple ...
Análisis topológico del interactoma de Helicobacter pylori revela proteínas topológicamente esenciales: identificación de blancos terapéuticos
(2014-01)
La Helicobacter pylori ha colonizado la mitad de la población mundial; su infección presenta una prevalencia
del 70% al 90% en países en vía de desarrollo y del 25% al 50% en países industrializados. Está establecido
que ...
Physiological copper exposure in Jurkat cells induces changes in the expression of genes encoding cholesterol biosynthesis proteins
(Springer, 2013)
Copper is an essential micronutrient that
functions as an enzymatic cofactor in a wide range of
cellular processes. Although adequate Cu levels are
essential for normal metabolism, excess Cu can be
toxic to cells. ...
Structures of parasite calreticulins provide insights into their flexibility and dual carbohydrate/peptide-binding properties
(Int Union Crystallography, 2016)
Calreticulin (CRT) is a multifaceted protein, initially discovered as an endoplasmic reticulum (ER) chaperone protein, that is essential in calcium metabolism. Various implications in cancer, early development and immunology ...
Trpml controls actomyosin contractility and couples migration to phagocytosis in fly macrophages
(Rockefeller University Press, 2020)
Phagocytes use their actomyosin cytoskeleton to migrate as well as to probe their environment by phagocytosis or macropinocytosis. Although migration and extracellular material uptake have been shown to be coupled in some ...
Treatment of chronic renal failure: effects of a supplemented diet with essential amino acids Tratamiento de la insuficiencia renal crónica: efectos de una dieta suplementada con aminoácidos esenciales.
(1990)
We evaluated the results of essential amino acids supplementation added to a protein restricted diet (0.6 g/kg/day) in patients with advanced renal failure (creatinine clearance under 20 ml/min). A diet containing food ...