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Immunization with antigen-pulsed dendritic cells significantly improves the immune response to weak self-antigens
(ELSEVIER GMBH, 2005-09-02)
Dendritic cells (DCs) are the only professional antigen-presenting cells endowed with the ability to stimulate naı¨ve T
cells and initiate a primary immune response. For this reason, DC-based immunization has been shown ...
Mind the gaps in tumor immunity: impact of connexin mediated intercellular connections
(Frontiers media SA, 2017)
Gap junctions (GJs)-mediated intercellular communications (GJICs) are connexin (Cx)-formed plasma membrane channels that allow for the passage of small molecules between adjacent cells, and are involved in several ...
Th17 and Treg cells, two new lymphocyte subpopulations with a key role in the immune response against infection
(2008)
In addition to the T helper 1 (Th1) and Th2 lymphocyte subsets, two new subpopulations Th17 and regulatory T
(Treg) cells have recently been described. Th17 cells, which produce high levels of interleukin (IL)-17, ...
Therapeutic potential of hyporesponsive CD4(+) T cells in autoimmunity
(Frontiers Media, 2015)
The interaction between dendritic cells (DCs) and T cells is crucial on immunity or tolerance induction. In an immature or semi-mature state, DCs induce tolerance through T-cell deletion, generation of regulatory T cells, ...
Interleukin 10 decreases MICA expression on melanoma cell surface
(2011)
Natural-killer group 2, member D (NKG2D) binds to a variety of ligands, including the major histocompatibility complex (MHC)
class I chain-related proteins (MIC) and UL16-binding proteins (ULBP). It is regarded as a ...
Dopamine Receptor D3 Signaling on CD4(+) T Cells Favors Th1-and Th17-Mediated Immunity
(Amer Assoc Immunologists, 2016)
Dopamine receptor D3 (DRD3) expressed on CD4(+) T cells is required to promote neuroinflammation in a murine model of Parkinson's disease. However, how DRD3 signaling affects T cell-mediated immunity remains unknown. In ...
Alarmin’ immunologists: iL-33 as a putative target for modulating T cell-dependent responses
(Frontiers Research Foundation, 2015)
IL-33 is a known member of the IL-1 cytokine superfamily classically named “atypical”
due to its diverse functions. The receptor for this cytokine is the ST2 chain (or IL-1RL1),
part of the IL-1R family, and the accessory ...
Vaccination-induced skin-resident memory CD8(+) T cells mediate strong protection against cutaneous melanoma
(Taylor & Francis, 2018)
Memory CD8(+) T cell responses have the potential to mediate long-lasting protection against cancers. Resident memory CD8(+) T (Trm) cells stably reside in non-lymphoid tissues and mediate superior innate and adaptive ...
IL-33 Alarmin and its active proinflammatory fragments are released in small intestine in celiac disease
(Frontiers Media, 2020)
Initially described as Th2 promoter cytokine, more recently, IL-33 has been recognized as an alarmin, mainly in epithelial and endothelial cells. While localized in the nucleus acting as a gene regulator, it can be also ...
T regulatory cells-derived extracellular vesicles and their contribution to the generation of immune tolerance
(Wiley, 2020)
T regulatory (Treg) cells have a major role in the maintenance of immune tolerance against self and foreign antigens through the control of harmful inflammation. Treg cells exert immunosuppressive function by several ...