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The STIM1 inhibitor ML9 disrupts basal autophagy in cardiomyocytes by decreasing lysosome content
(Elsevier, 2018)
Stromal-interaction molecule 1 (STIM1)-mediated store-operated Ca2+ entry (SOCE) plays a key role in mediating cardiomyocyte hypertrophy, both in vitro and in vivo. Moreover, there is growing support for the contribution ...
GDF11 Modulates Ca2+-Dependent Smad2/3 signaling to prevent cardiomyocyte hypertrophy
(MDPI, 2018-05)
Growth differentiation factor 11 (GDF11), a member of the transforming growth factor- family, has been shown to act as a negative regulator in cardiac hypertrophy. Ca2+ signaling modulates cardiomyocyte growth; however, ...
Ca-v beta(2) transcription start site variants modulate calcium handling in newborn rat cardiomyocytes
(Springer, 2015)
In the heart, the main pathway for calcium influx is mediated by L-type calcium channels, a multi-subunit complex composed of the pore-forming subunit Ca(V)1.2 and the auxiliary subunits Ca-V alpha(2)delta(1) and Ca-V ...
Cytotoxicity of snake venom Lys49 PLA2-like myotoxin on rat cardiomyocytes ex vivo does not involve a direct action on the contractile apparatus
(2021-09)
Viperid snake venoms contain a unique family of cytotoxic proteins, the Lys49 PLA2 homologs, which are devoid of enzymatic activity but disrupt the integrity of cell membranes. They are known to induce skeletal muscle ...
Targeting the cardiomyocyte cell cycle for heart regeneration
(Bentham Science Publishers, 2018-08)
Adult mammalian cardiomyocytes (CMs) exhibit limited proliferative capacity, as cell cycle activity leads to an increase in DNA content, but mitosis and cytokinesis are infrequent. This makes the heart highly inefficient ...
Direct and indirect effect of air particles exposure induce Nrf2-dependent cardiomyocyte cellular Response In Vitro
(Humana Press, 2019-05)
Air particulate matter has been associated with adverse effects in the cardiorespiratory system leading to cytotoxic and pro-inflammatory effects. Particulate matter-associated cardiac effects may be direct or indirect. ...
Action of propranolol on the atrial cardiomyocytes of rats submitted to cold stress
(Editrice Compositori Bologna, 1992-04-01)
Subcellular changes of the atrial cardiomyocytes of rats caused by cold showed a) altered mitochondria with edema and lysis of crests; b) myofibrils with marked heterogeneity of patterns and ruptures, c) myofilaments ...
Trimetazidine prevents palmitate-induced mitochondrial fission and dysfunction in cultured cardiomyocytes
(Elsevier Inc., 2014)
© 2014 Elsevier Inc. All rights reserved. Metabolic and cardiovascular disease patients have increased plasma levels of lipids and, specifically, of palmitate, which can be toxic for several tissues. Trimetazidine (TMZ), ...
Identification, Selection, and Enrichment of Cardiomyocyte Precursors
(Hindawi Publishing Corporation, 2013-01-01)
The large-scale production of cardiomyocytes is a key step in the development of cell therapy and tissue engineering to treat cardiovascular diseases, particularly those caused by ischemia. the main objective of this study ...
Trypanosoma cruzi down-regulates mechanosensitive proteins in cardiomyocytes
(Fundação Oswaldo Cruz. Instituto Oswaldo Cruz., 2019)