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Extension into the entrance channel of HIV-1 reverse transcriptase—Crystallography and enhanced solubility
(Elsevier, 2013-08)
Non-nucleoside inhibitors of HIV-1 reverse transcriptase (HIV-RT) are reported that feature extension into the entrance channel near Glu138. Complexes of the parent anilinylpyrimidine 1 and the morpholinoethoxy analog 2j ...
Picomolar inhibitors of HIV-1 reverse transcriptase: Design and crystallography of naphthyl phenyl ethers
(American Chemical Society, 2014-11)
Catechol diethers that incorporate a 6-cyano-1-naphthyl substituent have been explored as non-nucleoside inhibitors of HIV-1 reverse transcriptase (NNRTIs). Promising compounds are reported that show midpicomolar activity ...
Duration of Anti-Tuberculosis Therapy and Timing of Antiretroviral Therapy Initiation: Association with Mortality in HIV-Related Tuberculosis
(Public Library of Science, 2013)
Background: Antiretroviral therapy (ART) decreases mortality risk in HIV-infected tuberculosis patients, but the effect of the duration of anti-tuberculosis therapy and timing of anti-tuberculosis therapy initiation in ...
Fatores relacionados à adesão ao tratamento antirretroviral de adultos com HIV/AIDS
(Universidade Federal de Santa MariaBREnfermagemUFSMPrograma de Pós-Graduação em Enfermagem, 2013-05-06)
The objective was to analyze the factors related to the adherence to the antiretroviral treatment of adults with HIV/AIDS, who were treated at the University Hospital of Santa Maria. This is a cross-sectional study, with ...
O papel do exercício na era da terapia anti-retroviral fortemente ativaThe role of exercise in the era of highly active an tiretroviral therapy
(Universidade Católica de Brasília, 2014)
Assessing HIV resistance in developing countries: Brazil as a case study
(Organización Panamericana de la Salud, 2010)
Prevalência de resistência transmitida do HIV-1 aos antirretrovirais no Brasil, pré- início de tratamento
(Universidade Federal de São Paulo (UNIFESP), 2011-09-28)
The selection of resistance mutations to antiretroviral drugs after failure of antiretroviral therapy represents a major challenge for decision-making of new therapeutic regimens in the global pandemic. The high genetic ...
Tendência da transmissão vertical de Aids após terapia anti-retroviral no Brasil
(2006)
OBJETIVO: O crescimento de casos de Aids entre mulheres teve como conseqüência o aumento da transmissão vertical da infecção pelo vírus da imunodeficiência adquirida.
Medidas de controle dessa modalidade de transmissão ...