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Inhibition of tau phosphorylating protein kinase cdk5 prevents β-amyloid-induced neuronal death
(1999)
The key target of this study was the tau protein kinase II system (TPK II) involving the catalytic subunit cdk5 and the regulatory component p35. TPK II is one of the tau phosphorylating systems in neuronal cells, thus ...
Carbon Nanotubes Electrochemistry Allows the In Situ Evaluation of the Effect of β-Sheet Breakers on the Aggregation Process of β-Amyloid
(2012)
The inhibition of aggregation and disaggregation effect of a β-sheet breaker was evaluated by in situ electrochemistry of the Aβ 1-42 peptide. The exposition of 10tyr residue was followed using a carbon nanotubes modified ...
Cognitive impairment evaluation and management
To diagnose and treat a patient presenting with a cognitive complaint, the clinician
uses a systematic approach that identifies the presence and severity of the impairment, the cognitive domains involved, the likely ...
Functional and structural effects of amyloid-beta aggregate on Xenopus laevis oocytes
(KOREAN SOC MOLECULAR & CELLULAR BIOLOGY, 2012)
Correction: D-pinitol, a highly valuable product from carob pods: Healthpromoting effects and metabolic pathways of this natural super-food ingredient and its derivatives
The purpose of this note is to give some corrections for our published article in [1]. © 2021 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution ...
APP signaling in Alzheimer's disease
(Impact Journals, 2018-11)
A large body of evidence supports the Amyloid β (Aβ) cascade hypothesis underlying neurodegeneration in Alzheimer’s disease (AD). Although the mechanism by which Aβ induces neuronal dysfunction and death is still matter ...
New selective acetylcholinesterase inhibitors designed from natural piperidine alkaloids
(Elsevier B.V., 2005-07-01)
Five new piperidine alkaloids were designed from natural (-)-3-O-acetyl-spectaline and (-)-spectaline that were obtained from the flowers of Senna spectabilis (sin. Cassia spectabilis, Leguminosae). Two semi-synthetic ...